PDB entry 4ori

View 4ori on RCSB PDB site
Description: Rat dihydroorotate dehydrogenase bound with DSM338 (N-[3,5-difluoro-4-(trifluoromethyl)phenyl]-5-methyl-2-(trifluoromethyl)[1,2,4]triazolo[1,5-a]pyrimidin-7-amine)
Class: oxidoreductase/oxidoreductase inhibitor
Keywords: alpha/beta barrel, Oxidoreductase, FMN, mitochondrial membrane, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR complex
Deposited on 2014-02-11, released 2014-06-04
The last revision prior to the SCOPe 2.06 freeze date was dated 2014-07-09, with a file datestamp of 2014-07-03.
Experiment type: XRAY
Resolution: 1.5 Å
R-factor: 0.183
AEROSPACI score: 0.54 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Dihydroorotate dehydrogenase (quinone), mitochondrial
    Species: Rattus norvegicus [TaxId:10116]
    Gene: Dhodh, DIHYDROOROTATE DEHYDROGENASE
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d4oria_
  • Heterogens: FMN, ORO, 2V6, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4oriA (A:)
gddhfyaeylmpglqrlldpesahrlavrvtslgllpratfqdsdmlevkvlghkfrnpv
giaagfdkngeavdglyklgfgfvevgsvtpqpqegnprprvfrlpedqavinrygfnsh
glsvvehrlrarqqkqaqltadglplginlgknktsedaaadyaegvrtlgpladylvvn
vsspntaglrslqgktelrhllskvlqerdalkgtrkpavlvkiapdltaqdkediasva
relgidglivtnttvsrpvglqgalrsetgglsgkplrdlstqtiremyaltqgripiig
vggvssgqdalekiqagaslvqlytaliflgppvvvrvkreleallkergfttvtdaiga
dhrrlehhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >4oriA (A:)
hfyaeylmpglqrlldpesahrlavrvtslgllpratfqdsdmlevkvlghkfrnpvgia
agfdkngeavdglyklgfgfvevgsvtpqpqegnprprvfrlpedqavinrygfnshgls
vvehrlrarqqkqaqltadglplginlgknktsedaaadyaegvrtlgpladylvvnvss
pntqgktelrhllskvlqerdalkgtrkpavlvkiapdltaqdkediasvarelgidgli
vtnttvsrpvglqgalrsetgglsgkplrdlstqtiremyaltqgripiigvggvssgqd
alekiqagaslvqlytaliflgppvvvrvkreleallkergfttvtdaigadhrr