PDB entry 4ohe

View 4ohe on RCSB PDB site
Description: LEOPARD Syndrome-Associated SHP2/G464A mutant
Class: hydrolase
Keywords: sh2 domain, phosphatase domain, hydrolase
Deposited on 2014-01-17, released 2014-09-24
The last revision prior to the SCOPe 2.07 freeze date was dated 2014-11-05, with a file datestamp of 2014-10-31.
Experiment type: XRAY
Resolution: 2.51 Å
R-factor: 0.19
AEROSPACI score: 0.26 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Tyrosine-protein phosphatase non-receptor type 11
    Species: Homo sapiens [TaxId:9606]
    Gene: PTP2C, PTPN11, SHPTP2
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q06124 (Start-527)
      • engineered mutation (463)
    Domains in SCOPe 2.07: d4ohea1, d4ohea2, d4ohea3
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4oheA (A:)
mtsrrwfhpnitgveaenllltrgvdgsflarpsksnpgdftlsvrrngavthikiqntg
dyydlyggekfatlaelvqyymehhgqlkekngdvielkyplncadptserwfhghlsgk
eaeklltekgkhgsflvresqshpgdfvlsvrtgddkgesndgkskvthvmircqelkyd
vgggerfdsltdlvehykknpmvetlgtvlqlkqplnttrinaaeiesrvrelsklaett
dkvkqgfweefetlqqqeckllysrkegqrqenknknryknilpfdhtrvvlhdgdpnep
vsdyinaniimpefetkcnnskpkksyiatqgclqntvndfwrmvfqensrvivmttkev
ergkskcvkywpdeyalkeygvmrvrnvkesaahdytlrelklskvgqgntertvwqyhf
rtwpdhgvpsdpggvldfleevhhkqesimdagpvvvhcsagiartgtfividilidiir
ekgvdcdidvpktiqmvrsqrsgmvqteaqyrfiymavqhyietlqrrlehhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >4oheA (A:)
srrwfhpnitgveaenllltrgvdgsflarpsksnpgdftlsvrrngavthikiqntgdy
ydlyggekfatlaelvqyymehhgqlkekngdvielkyplncadptserwfhghlsgkea
eklltekgkhgsflvresqshpgdfvlsvrtkskvthvmircqelkydvgggerfdsltd
lvehykknpmvetlgtvlqlkqplnttrinaaeiesrvrelskgfweefetlqqqeckll
ysrkegqrqenknknryknilpfdhtrvvlhdsdyinaniimpekksyiatqgclqntvn
dfwrmvfqensrvivmttkevergkskcvkywpdeyalkeygvmrvrnvkesaahdytlr
elklskvgqgntertvwqyhfrtwpdhgvpsdpggvldfleevhhkqesimdagpvvvhc
sagiartgtfividilidiirekgvdcdidvpktiqmvrsqrsgmvqteaqyrfiymavq
hyietlqrr