PDB entry 4o7u

View 4o7u on RCSB PDB site
Description: Etherocomplex of Enteroccocus faecalis thymidylate synthase with 5-hydroxymethilene-6-hydrofolic acid and the phtalimidic inhibitor SS7
Class: transferase/transferase inhibitor
Keywords: transferase, folate binding, transferase-transferase inhibitor complex
Deposited on 2013-12-26, released 2014-12-31
The last revision prior to the SCOPe 2.05 freeze date was dated 2014-12-31, with a file datestamp of 2014-12-26.
Experiment type: XRAY
Resolution: 2.4 Å
R-factor: 0.216
AEROSPACI score: 0.25 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Thymidylate synthase
    Species: Enterococcus faecalis [TaxId:226185]
    Gene: thyA, EF_1576
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d4o7ua_
  • Chain 'B':
    Compound: Thymidylate synthase
    Species: Enterococcus faecalis [TaxId:226185]
    Gene: thyA, EF_1576
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d4o7ub_
  • Chain 'C':
    Compound: Thymidylate synthase
    Species: Enterococcus faecalis [TaxId:226185]
    Gene: thyA, EF_1576
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d4o7uc_
  • Chain 'D':
    Compound: Thymidylate synthase
    Species: Enterococcus faecalis [TaxId:226185]
    Gene: thyA, EF_1576
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d4o7ud_
  • Heterogens: SO4, THF, EDO, SS7, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4o7uA (A:)
meeaylalgkkileeghfkedrtgtgtyslfgyqmrfdlakgfpllttkrvpfgliksel
lwflkgdtniryllernnhiwdewaferyvksadyqgpdmtdfghrvlqdpafaeqykee
hqkfcdailndaefaekygelgniygaqwrhwetkdgsfidqlanviemiktnpdsrrli
vsawnpedvpsmalppchtmfqfyvnegklscqlyqrsadvflgvpfniasyallthlia
hetglevgefvhtlgdahlyqnhveqmqeqlsrevrsfptlvlnpdkasvfdfdmedikv
egydphptikapiav

    Sequence, based on observed residues (ATOM records): (download) 
    >4o7uA (A:)
meeaylalgkkileeghfkedrtgtgtyslfgyqmrfdlakgfpllttkrvpfgliksel
lwflkgdtniryllernnhiwdewaferyvksadyqykeehqkfcdailndaefaekyge
lgniygaqwrhwetkdgsfidqlanviemiktnpdsrrlivsawnpedvpsmalppchtm
fqfyvnegklscqlyqrsadvflgvpfniasyallthliahetglevgefvhtlgdahly
qnhveqmqeqlsrevrsfptlvlnpsvfdfdmedikvegydphptikapi

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4o7uB (B:)
meeaylalgkkileeghfkedrtgtgtyslfgyqmrfdlakgfpllttkrvpfgliksel
lwflkgdtniryllernnhiwdewaferyvksadyqgpdmtdfghrvlqdpafaeqykee
hqkfcdailndaefaekygelgniygaqwrhwetkdgsfidqlanviemiktnpdsrrli
vsawnpedvpsmalppchtmfqfyvnegklscqlyqrsadvflgvpfniasyallthlia
hetglevgefvhtlgdahlyqnhveqmqeqlsrevrsfptlvlnpdkasvfdfdmedikv
egydphptikapiav

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >4o7uC (C:)
meeaylalgkkileeghfkedrtgtgtyslfgyqmrfdlakgfpllttkrvpfgliksel
lwflkgdtniryllernnhiwdewaferyvksadyqgpdmtdfghrvlqdpafaeqykee
hqkfcdailndaefaekygelgniygaqwrhwetkdgsfidqlanviemiktnpdsrrli
vsawnpedvpsmalppchtmfqfyvnegklscqlyqrsadvflgvpfniasyallthlia
hetglevgefvhtlgdahlyqnhveqmqeqlsrevrsfptlvlnpdkasvfdfdmedikv
egydphptikapiav

    Sequence, based on observed residues (ATOM records): (download) 
    >4o7uC (C:)
meeaylalgkkileeghfkedrtgtgtyslfgyqmrfdlakgfpllttkrvpfgliksel
lwflkgdtniryllernnhiwdewaferyvkefaekygelgniygaqwrhwetkdgsfid
qlanviemiktnpdsrrlivsawnpedvpsmalppchtmfqfyvnegklscqlyqrsadv
flgvpfniasyallthliahetglevgefvhtlgdahlyqnhveqmqeqlsrevrsfptl
vlnpdkasvfdfdmedikvegydphptikapi

  • Chain 'D':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4o7uD (D:)
meeaylalgkkileeghfkedrtgtgtyslfgyqmrfdlakgfpllttkrvpfgliksel
lwflkgdtniryllernnhiwdewaferyvksadyqgpdmtdfghrvlqdpafaeqykee
hqkfcdailndaefaekygelgniygaqwrhwetkdgsfidqlanviemiktnpdsrrli
vsawnpedvpsmalppchtmfqfyvnegklscqlyqrsadvflgvpfniasyallthlia
hetglevgefvhtlgdahlyqnhveqmqeqlsrevrsfptlvlnpdkasvfdfdmedikv
egydphptikapiav