PDB entry 4o0x

View 4o0x on RCSB PDB site
Description: Back pocket flexibility provides group-II PAK selectivity for type 1 kinase inhibitors
Class: transferase/transferase inhibitor
Keywords: PAK4, transferase-transferase inhibitor complex
Deposited on 2013-12-14, released 2014-02-12
The last revision prior to the SCOPe 2.04 freeze date was dated 2014-02-26, with a file datestamp of 2014-02-21.
Experiment type: XRAY
Resolution: 2.48 Å
R-factor: 0.205
AEROSPACI score: 0.25 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: serine/threonine-protein kinase pak 4
    Species: Homo sapiens [TaxId:9606]
    Gene: PAK4, KIAA1142
    Database cross-references and differences (RAF-indexed):
    • Uniprot O96013 (1-End)
      • expression tag (0)
    Domains in SCOPe 2.04: d4o0xa_
  • Heterogens: 2OQ, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4o0xA (A:)
gsheqfraalqlvvdpgdprsyldnfikigegstgivciatvrssgklvavkkmdlrkqq
rrellfnevvimrdyqhenvvemynsylvgdelwvvmefleggaltdivthtrmneeqia
avclavlqalsvlhaqgvihrdiksdsillthdgrvklsdfgfcaqvskevprrkslvgt
pywmapelisrlpygpevdiwslgimviemvdgeppyfnepplkamkmirdnlpprlknl
hkvspslkgfldrllvrdpaqrataaellkhpflakagppasivplmrqnrtr

    Sequence, based on observed residues (ATOM records): (download) 
    >4o0xA (A:)
gsheqfraalqlvvdpgdprsyldnfikigegstgivciatvrssgklvavkkmdlrkqq
rrellfnevvimrdyqhenvvemynsylvgdelwvvmefleggaltdivthtrmneeqia
avclavlqalsvlhaqgvihrdiksdsillthdgrvklsdfgfcaqvskevprrkslvgt
pywmapelisrlpygpevdiwslgimviemvdgeppyfnepplkamkmirdnlpprlknl
hkvspslkgfldrllvrdpaqrataaellkhpflakagppasivplmrqnr