PDB entry 4mlh

View 4mlh on RCSB PDB site
Description: Human Glucokinase in Complex with a Novel Amino Thiazole Allosteric Activator
Class: transferase/transferase activator
Keywords: sugar kinase, allosteric activator, small molecule, TRANSFERASE-TRANSFERASE ACTIVATOR complex
Deposited on 2013-09-06, released 2013-09-25
The last revision prior to the SCOPe 2.04 freeze date was dated 2013-10-23, with a file datestamp of 2013-10-18.
Experiment type: XRAY
Resolution: 2.9 Å
R-factor: 0.222
AEROSPACI score: 0.17 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Glucokinase
    Species: Homo sapiens [TaxId:9606]
    Gene: GCK
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d4mlha1, d4mlha2
  • Heterogens: GLC, VO2

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4mlhA (A:)
maltlveqilaefqlqeedlkkvmrrmqkemdrglrletheeasvkmlptyvrstpegse
vgdflsldlggtnfrvmlvkvgegeegqwsvktkhqmysipedamtgtaemlfdyiseci
sdfldkhqmkhkklplgftfsfpvrhedidkgillnwtkgfkasgaegnnvvgllrdaik
rrgdfemdvvamvndtvatmiscyyedhqcevgmivgtgcnacymeemqnvelvegdegr
mcvntewgafgdsgeldeflleydrlvdessanpgqqlyekliggkymgelvrlvllrlv
denllfhgeaseqlrtrgafetrfvsqvesdtgdrkqiynilstlglrpsttdcdivrra
cesvstraahmcsaglagvinrmresrsedvmritvgvdgsvyklhpsfkerfhasvrrl
tpsceitfieseegsgrgaalvsavackkacmlgq

    Sequence, based on observed residues (ATOM records): (download) 
    >4mlhA (A:)
tlveqilaefqlqeedlkkvmrrmqkemdrglrletheeasvkmlptyvrstpegsevgd
flsldlggtnfrvmlvkvgegeegqwsvktkhqmysipedamtgtaemlfdyisecisdf
ldkhqmkhkklplgftfsfpvrhedidkgillnwtkgfkasgaegnnvvgllrdaikrrg
dfemdvvamvndtvatmiscyyedhqcevgmivgtgcnacymeemqnvelvegdegrmcv
ntewgafgdsgeldeflleydrlvdessanpgqqlyekliggkymgelvrlvllrlvden
llfhgeaseqlrtrgafetrfvsqvesdtgdrkqiynilstlglrpsttdcdivrraces
vstraahmcsaglagvinrmresrsedvmritvgvdgsvyklhpsfkerfhasvrrltps
ceitfieseegsgrgaalvsavackkac