PDB entry 4lrt
View 4lrt on RCSB PDB site
Description: Crystal and solution structures of the bifunctional enzyme (Aldolase/Aldehyde dehydrogenase) from Thermomonospora curvata, reveal a cofactor-binding domain motion during NAD+ and CoA accommodation whithin the shared cofactor-binding site
Class: Lyase/OXIDOREDUCTASE
Keywords: Rosmmann Fold, TIM barrel, Dehydrogenase, aldolase, Lyase-OXIDOREDUCTASE complex
Deposited on
2013-07-20, released
2013-09-04
The last revision prior to the SCOPe 2.08 freeze date was dated
2013-09-04, with a file datestamp of
2013-08-30.
Experiment type: XRAY
Resolution: 1.5 Å
R-factor: 0.152
AEROSPACI score: 0.58
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: 4-hydroxy-2-oxovalerate aldolase
Species: Thermomonospora curvata [TaxId:471852]
Gene: Tcur_0536
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d4lrta1, d4lrta2 - Chain 'B':
Compound: Acetaldehyde dehydrogenase
Species: Thermomonospora curvata [TaxId:471852]
Gene: Tcur_0535
Database cross-references and differences (RAF-indexed):
- Chain 'C':
Compound: 4-hydroxy-2-oxovalerate aldolase
Species: Thermomonospora curvata [TaxId:471852]
Gene: Tcur_0536
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d4lrtc1, d4lrtc2 - Chain 'D':
Compound: Acetaldehyde dehydrogenase
Species: Thermomonospora curvata [TaxId:471852]
Gene: Tcur_0535
Database cross-references and differences (RAF-indexed):
- Heterogens: PYR, NA, MG, SO4, GOL, COA, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>4lrtA (A:)
mtdqdgataaprvritdstlrdgshamahqfteeqvratvhaldaagvevievshgdglg
gssfnygfsavdeidlvaaavdeavnakiavlllpgvgtvrdlkrahdagasvariathc
teadvscqhfaaarelgmetvgflmlahrigpeelarqarimvdagaqcvyvvdsagalv
lsdvqarvqalvreigheaqvgfhghqnlslgvansvlayqngarqidgalcalgagagn
spteilaatferlnietgvnvqaalaaaeevvrpylprlpwadraaivqgyagvyssfll
haeraaerygvpaheilqrvgeagyvggqedmiidiavqlaeerhgrpapaggrr
Sequence, based on observed residues (ATOM records): (download)
>4lrtA (A:)
aprvritdstlrdgshamahqfteeqvratvhaldaagvevievshgdglggssfnygfs
avdeidlvaaavdeavnakiavlllpgvgtvrdlkrahdagasvariathcteadvscqh
faaarelgmetvgflmlahrigpeelarqarimvdagaqcvyvvdsagalvlsdvqarvq
alvreigheaqvgfhghqnlslgvansvlayqngarqidgalcalgagagnspteilaat
ferlnietgvnvqaalaaaeevvrpylprlpwadraaivqgyagvyssfllhaeraaery
gvpaheilqrvgeagyvggqedmiidiavqlaee
- Chain 'B':
No sequence available.
- Chain 'C':
Sequence, based on SEQRES records: (download)
>4lrtC (C:)
mtdqdgataaprvritdstlrdgshamahqfteeqvratvhaldaagvevievshgdglg
gssfnygfsavdeidlvaaavdeavnakiavlllpgvgtvrdlkrahdagasvariathc
teadvscqhfaaarelgmetvgflmlahrigpeelarqarimvdagaqcvyvvdsagalv
lsdvqarvqalvreigheaqvgfhghqnlslgvansvlayqngarqidgalcalgagagn
spteilaatferlnietgvnvqaalaaaeevvrpylprlpwadraaivqgyagvyssfll
haeraaerygvpaheilqrvgeagyvggqedmiidiavqlaeerhgrpapaggrr
Sequence, based on observed residues (ATOM records): (download)
>4lrtC (C:)
prvritdstlrdgshamahqfteeqvratvhaldaagvevievshgdglggssfnygfsa
vdeidlvaaavdeavnakiavlllpgvgtvrdlkrahdagasvariathcteadvscqhf
aaarelgmetvgflmlahrigpeelarqarimvdagaqcvyvvdsagalvlsdvqarvqa
lvreigheaqvgfhghqnlslgvansvlayqngarqidgalcalgagagnspteilaatf
erlnietgvnvqaalaaaeevvrpylprlpwadraaivqgyagvyssfllhaeraaeryg
vpaheilqrvgeagyvggqedmiidiavqlaeerh
- Chain 'D':
No sequence available.