PDB entry 4lo9

View 4lo9 on RCSB PDB site
Description: Human p53 Core Domain Mutant N235K
Class: apoptosis
Keywords: Beta Sandwich, Tumor Suppressor, DNA Binding, Nuclear, APOPTOSIS
Deposited on 2013-07-12, released 2013-07-31
The last revision prior to the SCOPe 2.06 freeze date was dated 2014-01-15, with a file datestamp of 2014-01-10.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: 0.181
AEROSPACI score: 0.28 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Cellular tumor antigen p53
    Species: Homo sapiens [TaxId:9606]
    Gene: P53, TP53
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04637
      • engineered mutation (141)
    Domains in SCOPe 2.06: d4lo9a_
  • Chain 'B':
    Compound: Cellular tumor antigen p53
    Species: Homo sapiens [TaxId:9606]
    Gene: P53, TP53
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04637
      • engineered mutation (141)
    Domains in SCOPe 2.06: d4lo9b_
  • Chain 'C':
    Compound: Cellular tumor antigen p53
    Species: Homo sapiens [TaxId:9606]
    Gene: P53, TP53
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04637
      • engineered mutation (141)
    Domains in SCOPe 2.06: d4lo9c_
  • Chain 'D':
    Compound: Cellular tumor antigen p53
    Species: Homo sapiens [TaxId:9606]
    Gene: P53, TP53
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04637
      • engineered mutation (141)
    Domains in SCOPe 2.06: d4lo9d_
  • Heterogens: ZN, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4lo9A (A:)
sssvpsqktyqgsygfrlgflhsgtaksvtctyspalnkmfcqlaktcpvqlwvdstppp
gtrvramaiykqsqhmtevvrrcphhercsdsdglappqhlirvegnlrveylddrntfr
hsvvvpyeppevgsdcttihykymcnsscmggmnrrpiltiitledssgnllgrnsfevr
vcacpgrdrrteeenlrkkgephhelppgstkralpnnt

    Sequence, based on observed residues (ATOM records): (download) 
    >4lo9A (A:)
svpsqktyqgsygfrlgflhsgtaksvtctyspalnkmfcqlaktcpvqlwvdstpppgt
rvramaiykqsqhmtevvrrcphhercsdsdglappqhlirvegnlrveylddrntfrhs
vvvpyeppevgsdcttihykymcnsscmggmnrrpiltiitledssgnllgrnsfevrvc
acpgrdrrteeenl

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4lo9B (B:)
sssvpsqktyqgsygfrlgflhsgtaksvtctyspalnkmfcqlaktcpvqlwvdstppp
gtrvramaiykqsqhmtevvrrcphhercsdsdglappqhlirvegnlrveylddrntfr
hsvvvpyeppevgsdcttihykymcnsscmggmnrrpiltiitledssgnllgrnsfevr
vcacpgrdrrteeenlrkkgephhelppgstkralpnnt

    Sequence, based on observed residues (ATOM records): (download) 
    >4lo9B (B:)
svpsqktyqgsygfrlgflhsgtaksvtctyspalnkmfcqlaktcpvqlwvdstpppgt
rvramaiykqsqhmtevvrrcphhercsdsdglappqhlirvegnlrveylddrntfrhs
vvvpyeppevgsdcttihykymcnsscmggmnrrpiltiitledssgnllgrnsfevrvc
acpgrdrrteeenl

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >4lo9C (C:)
sssvpsqktyqgsygfrlgflhsgtaksvtctyspalnkmfcqlaktcpvqlwvdstppp
gtrvramaiykqsqhmtevvrrcphhercsdsdglappqhlirvegnlrveylddrntfr
hsvvvpyeppevgsdcttihykymcnsscmggmnrrpiltiitledssgnllgrnsfevr
vcacpgrdrrteeenlrkkgephhelppgstkralpnnt

    Sequence, based on observed residues (ATOM records): (download) 
    >4lo9C (C:)
svpsqktyqgsygfrlgflhsgtaksvtctyspalnkmfcqlaktcpvqlwvdstpppgt
rvramaiykqsqhmtevvrrcphhercsdsdglappqhlirvegnlrveylddrntfrhs
vvvpyeppevgsdcttihykymcnsscmggmnrrpiltiitledssgnllgrnsfevrvc
acpgrdrrteeenl

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >4lo9D (D:)
sssvpsqktyqgsygfrlgflhsgtaksvtctyspalnkmfcqlaktcpvqlwvdstppp
gtrvramaiykqsqhmtevvrrcphhercsdsdglappqhlirvegnlrveylddrntfr
hsvvvpyeppevgsdcttihykymcnsscmggmnrrpiltiitledssgnllgrnsfevr
vcacpgrdrrteeenlrkkgephhelppgstkralpnnt

    Sequence, based on observed residues (ATOM records): (download) 
    >4lo9D (D:)
svpsqktyqgsygfrlgflhsgtaksvtctyspalnkmfcqlaktcpvqlwvdstpppgt
rvramaiykqsqhmtevvrrcphhercsdsdglappqhlirvegnlrveylddrntfrhs
vvvpyeppevgsdcttihykymcnsscmggmnrrpiltiitledssgnllgrnsfevrvc
acpgrdrrteeenl