PDB entry 4lg4

View 4lg4 on RCSB PDB site
Description: Structural Basis for Autoactivation of Human Mst2 Kinase and Its Regulation by RASSF5
Class: signaling protein
Keywords: Hippo, Mst autoactivation, dimerization, SIGNALING PROTEIN
Deposited on 2013-06-27, released 2013-09-18
The last revision prior to the SCOPe 2.04 freeze date was dated 2013-10-30, with a file datestamp of 2013-10-25.
Experiment type: XRAY
Resolution: 2.42 Å
R-factor: 0.194
AEROSPACI score: 0.29 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Serine/threonine-protein kinase 3
    Species: Homo sapiens [TaxId:9606]
    Gene: STK3, KRS1, MST2
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q13188
      • engineered mutation (131)
    Domains in SCOPe 2.04: d4lg4a_
  • Chain 'B':
    Compound: Serine/threonine-protein kinase 3
    Species: Homo sapiens [TaxId:9606]
    Gene: STK3, KRS1, MST2
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q13188
      • engineered mutation (131)
    Domains in SCOPe 2.04: d4lg4b_
  • Chain 'C':
    Compound: Serine/threonine-protein kinase 3
    Species: Homo sapiens [TaxId:9606]
    Gene: STK3, KRS1, MST2
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q13188
      • engineered mutation (131)
    Domains in SCOPe 2.04: d4lg4c_
  • Chain 'D':
    Compound: Serine/threonine-protein kinase 3
    Species: Homo sapiens [TaxId:9606]
    Gene: STK3, KRS1, MST2
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q13188
      • engineered mutation (131)
    Domains in SCOPe 2.04: d4lg4d_
  • Chain 'E':
    Compound: Serine/threonine-protein kinase 3
    Species: Homo sapiens [TaxId:9606]
    Gene: STK3, KRS1, MST2
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q13188
      • engineered mutation (131)
    Domains in SCOPe 2.04: d4lg4e_
  • Chain 'F':
    Compound: Serine/threonine-protein kinase 3
    Species: Homo sapiens [TaxId:9606]
    Gene: STK3, KRS1, MST2
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q13188
      • engineered mutation (131)
    Domains in SCOPe 2.04: d4lg4f_
  • Heterogens: GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4lg4A (A:)
gedsltkqpeevfdvleklgegsygsvfkaihkesgqvvaikqvpvesdlqeiikeisim
qqcdspyvvkyygsyfkntdlwivmeycgagsvsdiirlrnktliedeiatilkstlkgl
eylhfmrkihrnikagnillnteghakladfgvagqltdtmakrntvigtpfwmapeviq
eigyncvadiwslgitsiemaegkppyadihpmraifmiptnppptfrkpelwsddftdf
vkkclvknpeqratatqllqhpfiknakpvsilrdliteameikakrheeqqreleeee

    Sequence, based on observed residues (ATOM records): (download) 
    >4lg4A (A:)
sltkqpeevfdvleklgeygsvfkaihkesgqvvaikqvpvesdlqeiikeisimqqcds
pyvvkyygsyfkntdlwivmeycgagsvsdiirlrnktliedeiatilkstlkgleylhf
mrkihrnikagnillnteghakladfgvagqltdtmakrntvigtpfwmapeviqeigyn
cvadiwslgitsiemaegkppyadihpmraifmiptnppptfrkpelwsddftdfvkkcl
vknpeqratatqllqhpfiknakpvsilrdliteameikakrheeqqre

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4lg4B (B:)
gedsltkqpeevfdvleklgegsygsvfkaihkesgqvvaikqvpvesdlqeiikeisim
qqcdspyvvkyygsyfkntdlwivmeycgagsvsdiirlrnktliedeiatilkstlkgl
eylhfmrkihrnikagnillnteghakladfgvagqltdtmakrntvigtpfwmapeviq
eigyncvadiwslgitsiemaegkppyadihpmraifmiptnppptfrkpelwsddftdf
vkkclvknpeqratatqllqhpfiknakpvsilrdliteameikakrheeqqreleeee

    Sequence, based on observed residues (ATOM records): (download) 
    >4lg4B (B:)
sltkqpeevfdvleklgegsvfkaihkesgqvvaikqvpvesdlqeiikeisimqqcdsp
yvvkyygsyfkntdlwivmeycgagsvsdiirlrnktliedeiatilkstlkgleylhfm
rkihrnikagnillnteghakladfgltdtmakrntvigtpfwmapeviqeigyncvadi
wslgitsiemaegkppyadihpmraifmiptnppptfrkpelwsddftdfvkkclvknpe
qratatqllqhpfiknakpvsilrdliteameikakrheeqqre

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >4lg4C (C:)
gedsltkqpeevfdvleklgegsygsvfkaihkesgqvvaikqvpvesdlqeiikeisim
qqcdspyvvkyygsyfkntdlwivmeycgagsvsdiirlrnktliedeiatilkstlkgl
eylhfmrkihrnikagnillnteghakladfgvagqltdtmakrntvigtpfwmapeviq
eigyncvadiwslgitsiemaegkppyadihpmraifmiptnppptfrkpelwsddftdf
vkkclvknpeqratatqllqhpfiknakpvsilrdliteameikakrheeqqreleeee

    Sequence, based on observed residues (ATOM records): (download) 
    >4lg4C (C:)
sltkqpeevfdvleklgeggsvfkaihkesgqvvaikqvpvesdlqeiikeisimqqcds
pyvvkyygsyfkntdlwivmeycgagsvsdiirlrnktliedeiatilkstlkgleylhf
mrkihrnikagnillnteghakladfgvagqltdtmakrntvigtpfwmapeviqeigyn
cvadiwslgitsiemaegkppyadihpmraifmiptnppptfrkpelwsddftdfvkkcl
vknpeqratatqllqhpfiknakpvsilrdliteameikakrheeqqr

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >4lg4D (D:)
gedsltkqpeevfdvleklgegsygsvfkaihkesgqvvaikqvpvesdlqeiikeisim
qqcdspyvvkyygsyfkntdlwivmeycgagsvsdiirlrnktliedeiatilkstlkgl
eylhfmrkihrnikagnillnteghakladfgvagqltdtmakrntvigtpfwmapeviq
eigyncvadiwslgitsiemaegkppyadihpmraifmiptnppptfrkpelwsddftdf
vkkclvknpeqratatqllqhpfiknakpvsilrdliteameikakrheeqqreleeee

    Sequence, based on observed residues (ATOM records): (download) 
    >4lg4D (D:)
vfdvleklgeggsvfkaihkvvaikqdlqeiikeisimqqcdspyvvkyygsyfkwivme
ycgagsvsdiirlrnktliedeiatilkstlkgleylhfmrkihrnikagnillntegha
kladgtpfwmapeviqeigyncvadiwslgitsiemaegkppyadihpmraifmiptnpp
ptfrkpelwsddftdfvkkclvknpeqratatqllqhpfiknakpvsilrdliteameik
akrheeqqre

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >4lg4E (E:)
gedsltkqpeevfdvleklgegsygsvfkaihkesgqvvaikqvpvesdlqeiikeisim
qqcdspyvvkyygsyfkntdlwivmeycgagsvsdiirlrnktliedeiatilkstlkgl
eylhfmrkihrnikagnillnteghakladfgvagqltdtmakrntvigtpfwmapeviq
eigyncvadiwslgitsiemaegkppyadihpmraifmiptnppptfrkpelwsddftdf
vkkclvknpeqratatqllqhpfiknakpvsilrdliteameikakrheeqqreleeee

    Sequence, based on observed residues (ATOM records): (download) 
    >4lg4E (E:)
sltkqpeevfdvleklgsvfkaihkesgqvvaikqvlqeiikeisimqqcdspyvvkyyg
syfkntdlwivmeycgagsvsdiirlrnktliedeiatilkstlkgleylhfmrkihrni
kagnillnteghakladfgvagqltdtvigtpfwmapeviqeigyncvadiwslgitsie
maegkppyadihpmraifmiptnppptfrkpelwsddftdfvkkclvknpeqratatqll
qhpfiknakpvsilrdliteameikakrheeqqre

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >4lg4F (F:)
gedsltkqpeevfdvleklgegsygsvfkaihkesgqvvaikqvpvesdlqeiikeisim
qqcdspyvvkyygsyfkntdlwivmeycgagsvsdiirlrnktliedeiatilkstlkgl
eylhfmrkihrnikagnillnteghakladfgvagqltdtmakrntvigtpfwmapeviq
eigyncvadiwslgitsiemaegkppyadihpmraifmiptnppptfrkpelwsddftdf
vkkclvknpeqratatqllqhpfiknakpvsilrdliteameikakrheeqqreleeee

    Sequence, based on observed residues (ATOM records): (download) 
    >4lg4F (F:)
sltkqpeevfdvleklgegsygsvfkaihkesgqvvaikqvpvesdlqeiikeisimqqc
dspyvvkyygsyfkntdlwivmeycgagsvsdiirlrnktliedeiatilkstlkgleyl
hfmrkihrnikagnillnteghakladfgtpfwmapeviqeigyncvadiwslgitsiem
aegkppyadihpmraifmiptnppptfrkpelwsddftdfvkkclvknpeqratatqllq
hpfiknakpvsilrdliteameikakrheeqqrele