PDB entry 4l7d

View 4l7d on RCSB PDB site
Description: Structure of keap1 kelch domain with (1S,2R)-2-{[(1S)-5-methyl-1-[(1-oxo-1,3-dihydro-2H-isoindol-2-yl)methyl]-3,4-dihydroisoquinolin-2(1H)-yl]carbonyl}cyclohexanecarboxylic acid
Class: transcription/inhibitor
Keywords: STRESS SENSOR, KELCH DOMAIN, KELCH REPEAT MOTIF, BETA-PROPELLER, NRF2, PROTEIN-SMALL MOLECULE COMPLEX, TRANSCRIPTION-INHIBITOR complex
Deposited on 2013-06-13, released 2014-02-19
The last revision prior to the SCOPe 2.04 freeze date was dated 2014-02-19, with a file datestamp of 2014-02-14.
Experiment type: XRAY
Resolution: 2.25 Å
R-factor: 0.253
AEROSPACI score: 0.26 (click here for full SPACI score report)

Chains and heterogens:

• Chain 'A':
  Compound: Kelch-like ECH-associated protein 1
  Species: Homo sapiens [TaxId:9606]
  Gene: KEAP1, INRF2, KIAA0132, KLHL19
  Database cross-references and differences (RAF-indexed):
  • Uniprot Q14145 (Start-291)
    • engineered mutation (36)
    • expression tag (292-293)
  Domains in SCOPe 2.04: d4l7da_
• Chain 'B':
  Compound: Kelch-like ECH-associated protein 1
  Species: Homo sapiens [TaxId:9606]
  Gene: KEAP1, INRF2, KIAA0132, KLHL19
  Database cross-references and differences (RAF-indexed):
  • Uniprot Q14145 (Start-291)
    • engineered mutation (36)
    • expression tag (292)
• Chain 'C':
  Compound: Kelch-like ECH-associated protein 1
  Species: Homo sapiens [TaxId:9606]
  Gene: KEAP1, INRF2, KIAA0132, KLHL19
  Database cross-references and differences (RAF-indexed):
  • Uniprot Q14145 (Start-291)
    • engineered mutation (36)
    • expression tag (292-293)
• Heterogens: 1VX, ACT, HOH

PDB Chain Sequences:

• Chain 'A':
  Sequence, based on SEQRES records: (download)
  

  >4l7dA (A:)
  mghapkvgrliytaggyfrqslsyleaynpsdgtwldladlqvprsglagcvvggllyav
  ggrnnspdgntdssaldcynpmtnqwspcapmsvprnrigvgvidghiyavggshgcihh
  nsveryeperdewhlvapmltrrigvgvavlnrllyavggfdgtnrlnsaecyypernew
  rmitamntirsgagvcvlhnciyaaggydgqdqlnsverydvetetwtfvapmkhrrsal
  gitvhqgriyvlggydghtfldsvecydpdtdtwsevtrmtsgrsgvgvavtlehhhhhh
  

  
  Sequence, based on observed residues (ATOM records): (download)
  

  >4l7dA (A:)
  rliytaggyfrqslsyleaynpsdgtwldladlqvprsglagcvvggllyavggrnnspd
  gntdssaldcynpmtnqwspcapmsvprnrigvgvidghiyavggshgcihhnsveryep
  erdewhlvapmltrrigvgvavlnrllyavggfdgtnrlnsaecyypernewrmitamnt
  irsgagvcvlhnciyaaggydgqdqlnsverydvetetwtfvapmkhrrsalgitvhqgr
  iyvlggydghtfldsvecydpdtdtwsevtrmtsgrsgvgvavtle
  

  
  
• Chain 'B':
  No sequence available.
  
  
• Chain 'C':
  No sequence available.