PDB entry 4k26

View 4k26 on RCSB PDB site
Description: 4,4-Dioxo-5,6-dihydro-[1,4,3]oxathiazines, a novel class of 11 -HSD1 inhibitors for the treatment of diabetes
Class: oxidoreductase/oxidoreductase inhibitor
Keywords: Oxidoreductase, alpha and beta proteins, NAD(P)-binding Rossman-fold, short chain dehydrogenase, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR complex
Deposited on 2013-04-08, released 2014-04-09
The last revision prior to the SCOPe 2.07 freeze date was dated 2014-04-09, with a file datestamp of 2014-04-04.
Experiment type: XRAY
Resolution: 2.21 Å
R-factor: 0.168
AEROSPACI score: 0.34 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Corticosteroid 11-beta-dehydrogenase isozyme 1
    Species: Mus musculus [TaxId:10090]
    Gene: Hsd11b1, Hsd11
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d4k26a_
  • Chain 'B':
    Compound: Corticosteroid 11-beta-dehydrogenase isozyme 1
    Species: Mus musculus [TaxId:10090]
    Gene: Hsd11b1, Hsd11
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d4k26b_
  • Heterogens: SFF, SO4, NDP, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4k26A (A:)
mhhhhhhneefrpemlqgkkvivtgaskgigremayhlskmgahvvltarseeglqkvvs
rclelgaasahyiagtmedmtfaeqfivkagklmggldmlilnhitqtslslfhddihsv
rrvmevnflsyvvmstaalpmlkqsngsiavisslagkmtqpmiapysaskfaldgffst
irtelyitkvnvsitlcvlglidtetamkeisgiinaqaspkeecaleiikgtalrksev
yydkspltpillgnpgrkimeffslryynkdmfvsn

    Sequence, based on observed residues (ATOM records): (download) 
    >4k26A (A:)
eefrpemlqgkkvivtgaskgigremayhlskmgahvvltarseeglqkvvsrclelgaa
sahyiagtmedmtfaeqfivkagklmggldmlilnhitqtslslfhddihsvrrvmevnf
lsyvvmstaalpmlkqsngsiavisslagkmtqpmiapysaskfaldgffstirtelyit
kvnvsitlcvlglidtetamkeisgiinaqaspkeecaleiikgtalrksevyydksplt
pillgnpgrkimeffslryynkdmf

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4k26B (B:)
mhhhhhhneefrpemlqgkkvivtgaskgigremayhlskmgahvvltarseeglqkvvs
rclelgaasahyiagtmedmtfaeqfivkagklmggldmlilnhitqtslslfhddihsv
rrvmevnflsyvvmstaalpmlkqsngsiavisslagkmtqpmiapysaskfaldgffst
irtelyitkvnvsitlcvlglidtetamkeisgiinaqaspkeecaleiikgtalrksev
yydkspltpillgnpgrkimeffslryynkdmfvsn

    Sequence, based on observed residues (ATOM records): (download) 
    >4k26B (B:)
eefrpemlqgkkvivtgaskgigremayhlskmgahvvltarseeglqkvvsrclelgaa
sahyiagtmedmtfaeqfivkagklmggldmlilnhitqtslslfhddihsvrrvmevnf
lsyvvmstaalpmlkqsngsiavisslagkmtqpmiapysaskfaldgffstirtelyit
kvnvsitlcvlglidtetamkeisgiinaqaspkeecaleiikgtalrksevyydksplt
pillgnpgrkimeffslryynkdmf