PDB entry 4jtd
View 4jtd on RCSB PDB site
Description: Crystal structure of Kv1.2-2.1 paddle chimera channel in complex with Lys27Met mutant of Charybdotoxin
Class: TRANSPORT PROTEIN/toxin
Keywords: potassium channel, pore blocking toxin, protein-protein complex, trans-enhanced dissociation effect, TRANSPORT PROTEIN-toxin complex
Deposited on
2013-03-23, released
2013-06-12
The last revision prior to the SCOPe 2.06 freeze date was dated
2013-06-12, with a file datestamp of
2013-06-07.
Experiment type: XRAY
Resolution: 2.54 Å
R-factor: 0.21
AEROSPACI score: 0.33
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Voltage-gated potassium channel subunit beta-2
Species: Rattus norvegicus [TaxId:10116]
Gene: Ckbeta2, Kcnab2, Kcnb3
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.06: d4jtda_ - Chain 'B':
Compound: Potassium voltage-gated channel subfamily A member 2, Potassium voltage-gated channel subfamily B member 1
Species: Rattus norvegicus [TaxId:10116]
Gene: Kcna2, Kcnb1
Database cross-references and differences (RAF-indexed):
- Uniprot P63142 (Start-284)
- engineered mutation (50)
- engineered mutation (225)
- Uniprot P15387 (285-317)
- Uniprot P63142 (318-End)
- Chain 'G':
Compound: Voltage-gated potassium channel subunit beta-2
Species: Rattus norvegicus [TaxId:10116]
Gene: Ckbeta2, Kcnab2, Kcnb3
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.06: d4jtdg_ - Chain 'H':
Compound: Potassium voltage-gated channel subfamily A member 2, Potassium voltage-gated channel subfamily B member 1
Species: Rattus norvegicus [TaxId:10116]
Gene: Kcna2, Kcnb1
Database cross-references and differences (RAF-indexed):
- Uniprot P63142 (Start-284)
- engineered mutation (50)
- engineered mutation (225)
- Uniprot P15387 (285-317)
- Uniprot P63142 (318-End)
- Chain 'Y':
Compound: Potassium channel toxin alpha-KTx 1.1
Species: Leiurus quinquestriatus hebraeus [TaxId:6884]
Database cross-references and differences (RAF-indexed):
- Uniprot P13487 (0-36)
- modified residue (0)
- engineered mutation (26)
Domains in SCOPe 2.06: d4jtdy_ - Heterogens: NAP, K, PGW, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>4jtdA (A:)
mlqfyrnlgksglrvsclglgtwvtfggqitdemaehlmtlaydnginlfdtaevyaagk
aevvlgniikkkgwrrsslvittkifwggkaeterglsrkhiieglkaslerlqleyvdv
vfanrpdpntpmeetvramthvinqgmamywgtsrwssmeimeaysvarqfnlippiceq
aeyhmfqrekvevqlpelfhkigvgamtwsplacgivsgkydsgippysraslkgyqwlk
dkilseegrrqqaklkelqaiaerlgctlpqlaiawclrnegvssvllgasnaeqlmeni
gaiqvlpklsssivheidsilgnkpyskkdyrs
Sequence, based on observed residues (ATOM records): (download)
>4jtdA (A:)
lqfyrnlgksglrvsclglgtwvtfggqitdemaehlmtlaydnginlfdtaevyaagka
evvlgniikkkgwrrsslvittkifwggkaeterglsrkhiieglkaslerlqleyvdvv
fanrpdpntpmeetvramthvinqgmamywgtsrwssmeimeaysvarqfnlippiceqa
eyhmfqrekvevqlpelfhkigvgamtwsplacgivsgkydsgippysraslkgyqwlkd
kilseegrrqqaklkelqaiaerlgctlpqlaiawclrnegvssvllgasnaeqlmenig
aiqvlpklsssivheidsilgnkpys
- Chain 'B':
No sequence available.
- Chain 'G':
Sequence, based on SEQRES records: (download)
>4jtdG (G:)
mlqfyrnlgksglrvsclglgtwvtfggqitdemaehlmtlaydnginlfdtaevyaagk
aevvlgniikkkgwrrsslvittkifwggkaeterglsrkhiieglkaslerlqleyvdv
vfanrpdpntpmeetvramthvinqgmamywgtsrwssmeimeaysvarqfnlippiceq
aeyhmfqrekvevqlpelfhkigvgamtwsplacgivsgkydsgippysraslkgyqwlk
dkilseegrrqqaklkelqaiaerlgctlpqlaiawclrnegvssvllgasnaeqlmeni
gaiqvlpklsssivheidsilgnkpyskkdyrs
Sequence, based on observed residues (ATOM records): (download)
>4jtdG (G:)
lqfyrnlgksglrvsclglgtwvtfggqitdemaehlmtlaydnginlfdtaevyaagka
evvlgniikkkgwrrsslvittkifwggkaeterglsrkhiieglkaslerlqleyvdvv
fanrpdpntpmeetvramthvinqgmamywgtsrwssmeimeaysvarqfnlippiceqa
eyhmfqrekvevqlpelfhkigvgamtwsplacgivsgkydsgippysraslkgyqwlkd
kilseegrrqqaklkelqaiaerlgctlpqlaiawclrnegvssvllgasnaeqlmenig
aiqvlpklsssivheidsilgnkpys
- Chain 'H':
No sequence available.
- Chain 'Y':
Sequence; same for both SEQRES and ATOM records: (download)
>4jtdY (Y:)
eftnvscttskecwsvcqrlhntsrgmcmnkkcrcys