PDB entry 4jtc

View 4jtc on RCSB PDB site
Description: Crystal structure of Kv1.2-2.1 paddle chimera channel in complex with Charybdotoxin in Cs+
Class: TRANSPORT PROTEIN/toxin
Keywords: potassium channel, pore blocking toxin, protein-protein complex, TRANSPORT PROTEIN-toxin complex
Deposited on 2013-03-23, released 2013-06-12
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-11-15, with a file datestamp of 2017-11-10.
Experiment type: XRAY
Resolution: 2.56 Å
R-factor: N/A
AEROSPACI score: 0.2 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Voltage-gated potassium channel subunit beta-2
    Species: Rattus norvegicus [TaxId:10116]
    Gene: Ckbeta2, Kcnab2, Kcnb3
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d4jtca_
  • Chain 'B':
    Compound: Potassium voltage-gated channel subfamily A member 2, Potassium voltage-gated channel subfamily B member 1
    Species: Rattus norvegicus [TaxId:10116]
    Gene: Kcna2, Kcnb1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P63142 (Start-284)
      • engineered mutation (50)
      • engineered mutation (225)
    • Uniprot P15387 (285-317)
    • Uniprot P63142 (318-End)
  • Chain 'G':
    Compound: Voltage-gated potassium channel subunit beta-2
    Species: Rattus norvegicus [TaxId:10116]
    Gene: Ckbeta2, Kcnab2, Kcnb3
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d4jtcg_
  • Chain 'H':
    Compound: Potassium voltage-gated channel subfamily A member 2, Potassium voltage-gated channel subfamily B member 1
    Species: Rattus norvegicus [TaxId:10116]
    Gene: Kcna2, Kcnb1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P63142 (Start-284)
      • engineered mutation (50)
      • engineered mutation (225)
    • Uniprot P15387 (285-317)
    • Uniprot P63142 (318-End)
  • Chain 'Y':
    Compound: Potassium channel toxin alpha-KTx 1.1
    Species: Leiurus quinquestriatus hebraeus [TaxId:6884]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P13487 (0-36)
      • modified residue (0)
    Domains in SCOPe 2.07: d4jtcy_
  • Heterogens: NAP, CS, PGW

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4jtcA (A:)
mlqfyrnlgksglrvsclglgtwvtfggqitdemaehlmtlaydnginlfdtaevyaagk
aevvlgniikkkgwrrsslvittkifwggkaeterglsrkhiieglkaslerlqleyvdv
vfanrpdpntpmeetvramthvinqgmamywgtsrwssmeimeaysvarqfnlippiceq
aeyhmfqrekvevqlpelfhkigvgamtwsplacgivsgkydsgippysraslkgyqwlk
dkilseegrrqqaklkelqaiaerlgctlpqlaiawclrnegvssvllgasnaeqlmeni
gaiqvlpklsssivheidsilgnkpyskkdyrs

    Sequence, based on observed residues (ATOM records): (download) 
    >4jtcA (A:)
lqfyrnlgksglrvsclglgtwvtfggqitdemaehlmtlaydnginlfdtaevyaagka
evvlgniikkkgwrrsslvittkifwggkaeterglsrkhiieglkaslerlqleyvdvv
fanrpdpntpmeetvramthvinqgmamywgtsrwssmeimeaysvarqfnlippiceqa
eyhmfqrekvevqlpelfhkigvgamtwsplacgivsgkydsgippysraslkgyqwlkd
kilseegrrqqaklkelqaiaerlgctlpqlaiawclrnegvssvllgasnaeqlmenig
aiqvlpklsssivheidsilgnkpys

  • Chain 'B':
    No sequence available.

  • Chain 'G':
    Sequence, based on SEQRES records: (download) 
    >4jtcG (G:)
mlqfyrnlgksglrvsclglgtwvtfggqitdemaehlmtlaydnginlfdtaevyaagk
aevvlgniikkkgwrrsslvittkifwggkaeterglsrkhiieglkaslerlqleyvdv
vfanrpdpntpmeetvramthvinqgmamywgtsrwssmeimeaysvarqfnlippiceq
aeyhmfqrekvevqlpelfhkigvgamtwsplacgivsgkydsgippysraslkgyqwlk
dkilseegrrqqaklkelqaiaerlgctlpqlaiawclrnegvssvllgasnaeqlmeni
gaiqvlpklsssivheidsilgnkpyskkdyrs

    Sequence, based on observed residues (ATOM records): (download) 
    >4jtcG (G:)
lqfyrnlgksglrvsclglgtwvtfggqitdemaehlmtlaydnginlfdtaevyaagka
evvlgniikkkgwrrsslvittkifwggkaeterglsrkhiieglkaslerlqleyvdvv
fanrpdpntpmeetvramthvinqgmamywgtsrwssmeimeaysvarqfnlippiceqa
eyhmfqrekvevqlpelfhkigvgamtwsplacgivsgkydsgippysraslkgyqwlkd
kilseegrrqqaklkelqaiaerlgctlpqlaiawclrnegvssvllgasnaeqlmenig
aiqvlpklsssivheidsilgnkpys

  • Chain 'H':
    No sequence available.

  • Chain 'Y':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4jtcY (Y:)
eftnvscttskecwsvcqrlhntsrgkcmnkkcrcys