PDB entry 4jlt

View 4jlt on RCSB PDB site
Description: Crystal structure of P450 2B4(H226Y) in complex with paroxetine
Class: oxidoreductase
Keywords: P450, cytochrome P450 2B4, monooxygenase, oxidoreductase, ME protein, CYP 2B4
Deposited on 2013-03-13, released 2013-06-26
The last revision prior to the SCOPe 2.08 freeze date was dated 2013-07-03, with a file datestamp of 2013-06-28.
Experiment type: XRAY
Resolution: 2.14 Å
R-factor: 0.19
AEROSPACI score: 0.41 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Cytochrome P450 2B4
    Species: Oryctolagus cuniculus [TaxId:9986]
    Gene: CYP2B4
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00178 (Start-471)
      • engineered mutation (9)
      • see remark 999 (201)
      • engineered mutation (206)
      • expression tag (472)
    Domains in SCOPe 2.08: d4jlta1, d4jlta2
  • Heterogens: HEM, CM5, 8PR, SO4, GOL, PO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4jltA (A:)
makktsskgklppgpsplpvlgnllqmdrkgllrsflrlrekygdvftvylgsrpvvvlc
gtdairealvdqaeafsgrgkiavvdpifqgygvifangerwralrrfslatmrdfgmgk
rsveeriqeearclveelrkskgalldntllfhsitsniicsivfgkrfdykdpvflrll
dlffqsfslissfssqvfelfsgflkyfpgthrqiyrnlqeintfigqsvekhratldps
nprdfidvyllrmekdksdpssefhhqnliltvlslffagtettsttlrygfllmlkyph
vtervqkeieqvigshrppalddrakmpytdaviheiqrlgdlipfgvphtvtkdtqfrg
yvipkntevfpvlssalhdpryfetpntfnpghfldangalkrnegfmpfslgkriclge
giartelflffttilqnfsiaspvppedidltpresgvgnvppsyqirflarhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >4jltA (A:)
gklppgpsplpvlgnllqmdrkgllrsflrlrekygdvftvylgsrpvvvlcgtdairea
lvdqaeafsgrgkiavvdpifqgygvifangerwralrrfslatmrdrsveeriqeearc
lveelrkskgalldntllfhsitsniicsivfgkrfdykdpvflrlldlffqsfslissf
ssqvfelfsgflkyfpgthrqiyrnlqeintfigqsvekhratldpsnprdfidvyllrm
ekdksdpssefhhqnliltvlslffagtettsttlrygfllmlkyphvtervqkeieqvi
gshrppalddrakmpytdaviheiqrlgdlipfgvphtvtkdtqfrgyvipkntevfpvl
ssalhdpryfetpntfnpghfldangalkrnegfmpfslgkriclgegiartelflfftt
ilqnfsiaspvppedidltpsgvgnvppsyqirflarh