PDB entry 4iwv

View 4iwv on RCSB PDB site
Description: Crystals structure of Human Glucokinase in complex with small molecule activator
Class: transferase/transferase inhibitor
Keywords: Allosteric Site, Catalysis, Enzyme Activation, Gene Expression Regulation, Glucokinase, Glucose, Homeostasis, Humans, Hypoglycemia, Kinetics, Biological, Models, Molecular, Mutation, Protein Conformation, Scattering, Radiation, X-Rays, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on 2013-01-24, released 2013-04-24
The last revision prior to the SCOPe 2.04 freeze date was dated 2013-04-24, with a file datestamp of 2013-04-19.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: 0.202
AEROSPACI score: 0.4 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Glucokinase isoform 3
    Species: Homo sapiens [TaxId:9606]
    Gene: GCK
    Database cross-references and differences (RAF-indexed):
    • Uniprot P35557 (3-End)
      • expression tag (1-2)
      • engineered mutation (17-18)
      • engineered mutation (41-42)
    Domains in SCOPe 2.04: d4iwva1, d4iwva2
  • Heterogens: NA, GLC, 1J9, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4iwvA (A:)
gssnsqveqilaefqlqaadlkkvmrrmqkemdrglrlethaaasvkmlptyvrstpegs
evgdflsldlggtnfrvmlvkvgegeegqwsvktkhqmysipedamtgtaemlfdyisec
isdfldkhqmkhkklplgftfsfpvrhedidkgillnwtkgfkasgaegnnvvgllrdai
krrgdfemdvvamvndtvatmiscyyedhqcevgmivgtgcnacymeemqnvelvegdeg
rmcvntewgafgdsgeldeflleydrlvdessanpgqqlyekliggkymgelvrlvllrl
vdenllfhgeaseqlrtrgafetrfvsqvesdtgdrkqiynilstlglrpsttdcdivrr
acesvstraahmcsaglagvinrmresrsedvmritvgvdgsvyklhpsfkerfhasvrr
ltpsceitfieseegsgrgaalvsavackkacmlgq

    Sequence, based on observed residues (ATOM records): (download) 
    >4iwvA (A:)
ssnsqveqilaefqlqaadlkkvmrrmqkemdrglrlethaaasvkmlptyvrstpegse
vgdflsldlggtnfrvmlvkvgeqwsvktkhqmysipedamtgtaemlfdyisecisdfl
dkhqmkhkklplgftfsfpvrhedidkgillnwtkgfkasgaegnnvvgllrdaikrrgd
femdvvamvndtvatmiscyyedhqcevgmivgtgcnacymeemqnvelvegdegrmcvn
tewgafgdsgeldeflleydrlvdessanpgqqlyekliggkymgelvrlvllrlvdenl
lfhgeaseqlrtrgafetrfvsqvesgdrkqiynilstlglrpsttdcdivrracesvst
raahmcsaglagvinrmresrsedvmritvgvdgsvyklhpsfkerfhasvrrltpscei
tfieseegsgrgaalvsavackk