PDB entry 4isg

View 4isg on RCSB PDB site
Description: Human glucokinase in complex with novel activator (2S)-3-cyclohexyl-2-[4-(methylsulfonyl)-2-oxopiperazin-1-yl]-N-(1,3-thiazol-2-yl)propanamide
Class: transferase/transferase activator
Keywords: transferase/activator activity, glucose conversion to G6P, phosphorylation, TRANSFERASE-TRANSFERASE ACTIVATOR complex
Deposited on 2013-01-16, released 2013-03-20
The last revision prior to the SCOPe 2.05 freeze date was dated 2013-04-03, with a file datestamp of 2013-03-29.
Experiment type: XRAY
Resolution: 2.65 Å
R-factor: 0.203
AEROSPACI score: 0.3 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Glucokinase
    Species: Homo sapiens [TaxId:9606]
    Gene: GCK, HXK4 Isoform II
    Database cross-references and differences (RAF-indexed):
    • Uniprot P35557 (8-457)
      • expression tag (1-7)
    Domains in SCOPe 2.05: d4isga1, d4isga2
  • Heterogens: GLC, 1FY, IOD, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4isgA (A:)
mkpmpltlveqilaefqlqeedlkkvmrrmqkemdrglrletheeasvkmlptyvrstpe
gsevgdflsldlggtnfrvmlvkvgegeegqwsvktkhqmysipedamtgtaemlfdyis
ecisdfldkhqmkhkklplgftfsfpvrhedidkgillnwtkgfkasgaegnnvvgllrd
aikrrgdfemdvvamvndtvatmiscyyedhqcevgmivgtgcnacymeemqnvelvegd
egrmcvntewgafgdsgeldeflleydrlvdessanpgqqlyekliggkymgelvrlvll
rlvdenllfhgeaseqlrtrgafetrfvsqvesdtgdrkqiynilstlglrpsttdcdiv
rracesvstraahmcsaglagvinrmresrsedvmritvgvdgsvyklhpsfkerfhasv
rrltpsceitfieseegsgrgaalvsavackkacmlgq

    Sequence, based on observed residues (ATOM records): (download) 
    >4isgA (A:)
kpmpltlveqilaefqlqeedlkkvmrrmqkemdrglrletheeasvkmlptyvrstpeg
sevgdflsldlggtnfrvmlvkvgeqwsvktkhqmysipedamtgtaemlfdyisecisd
fldkhqmkhkklplgftfnvvgllrdaikrrgdfemdvvamvndtvatmiscyyedhqce
vgmivgtgcnacymeemqnvelvegdegrmcvntewgafgdsgeldeflleydrlvdess
anpgqqlyekliggkymgelvrlvllrlvdenllfhgeaseqlrtrgafetrfvsqvesd
tgdrkqiynilstlglrpsttdcdivrracesvstraahmcsaglagvinrmresrmrit
vgvdgsvyklhpsfkerfhasvrrltpsceitfiesesgrgaalvsavackkacmlgq