PDB entry 4isf

View 4isf on RCSB PDB site
Description: Human glucokinase in complex with novel activator (2S)-3-cyclohexyl-2-(6-fluoro-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)-N-(1,3-thiazol-2-yl)propanamide
Class: transferase/transferase activator
Keywords: transferase/activator activity, glucose conversion to G6P, phosphorylation, TRANSFERASE-TRANSFERASE ACTIVATOR complex
Deposited on 2013-01-16, released 2013-03-20
The last revision prior to the SCOPe 2.03 freeze date was dated 2013-04-03, with a file datestamp of 2013-03-29.
Experiment type: XRAY
Resolution: 2.09 Å
R-factor: 0.201
AEROSPACI score: 0.42 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Glucokinase
    Species: Homo sapiens [TaxId:9606]
    Gene: GCK, HXK4 Isoform II
    Database cross-references and differences (RAF-indexed):
    • Uniprot P35557 (8-457)
      • expression tag (1-7)
    Domains in SCOPe 2.03: d4isfa1, d4isfa2
  • Heterogens: GLC, 1FX, IOD, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4isfA (A:)
mkpmpltlveqilaefqlqeedlkkvmrrmqkemdrglrletheeasvkmlptyvrstpe
gsevgdflsldlggtnfrvmlvkvgegeegqwsvktkhqmysipedamtgtaemlfdyis
ecisdfldkhqmkhkklplgftfsfpvrhedidkgillnwtkgfkasgaegnnvvgllrd
aikrrgdfemdvvamvndtvatmiscyyedhqcevgmivgtgcnacymeemqnvelvegd
egrmcvntewgafgdsgeldeflleydrlvdessanpgqqlyekliggkymgelvrlvll
rlvdenllfhgeaseqlrtrgafetrfvsqvesdtgdrkqiynilstlglrpsttdcdiv
rracesvstraahmcsaglagvinrmresrsedvmritvgvdgsvyklhpsfkerfhasv
rrltpsceitfieseegsgrgaalvsavackkacmlgq

    Sequence, based on observed residues (ATOM records): (download) 
    >4isfA (A:)
kpmpltlveqilaefqlqeedlkkvmrrmqkemdrglrletheeasvkmlptyvrstpse
vgdflsldlggtnfrvmlvkvgeqwsvktkhqmysipedamtgtaemlfdyisecisdfl
dkhqmkhkklplgftfsfpvrhnvvgllrdaikrrgdfemdvvamvndtvatmiscyyed
hqcevgmivgtgcnacymeemqnvelvegdegrmcvntewgafgdsgeldeflleydrlv
dessanpgqqlyekliggkymgelvrlvllrlvdenllfhgeaseqlrtrgafetrfvsq
vesdtgdrkqiynilstlglrpsttdcdivrracesvstraahmcsaglagvinrmresr
sedvmritvgvdgsvyklhpsfkerfhasvrrltpsceitfieseegsgrgaalvsavac
kkacmlgq