PDB entry 4i87
View 4i87 on RCSB PDB site
Description: Crystal structure of TTR variant I84S in complex with CHF5074 at acidic pH
Class: transport protein/inhibitor
Keywords: Transthyretin, amyloidosis, fibrillogenesis inhibitors, protein misfolding, T3 or T4 hormone, Plasma, transport protein-inhibitor complex
Deposited on
2012-12-03, released
2013-06-19
The last revision prior to the SCOPe 2.04 freeze date was dated
2013-08-07, with a file datestamp of
2013-08-02.
Experiment type: XRAY
Resolution: 1.69 Å
R-factor: 0.176
AEROSPACI score: 0.56
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Transthyretin
Species: Homo sapiens [TaxId:9606]
Gene: PALB, TTR
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.04: d4i87a_ - Chain 'B':
Compound: Transthyretin
Species: Homo sapiens [TaxId:9606]
Gene: PALB, TTR
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.04: d4i87b_ - Heterogens: H50, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>4i87A (A:)
gptgtgeskcplmvkvldavrgspainvavhvfrkaaddtwepfasgktsesgelhgltt
eeefvegiykveidtksywkalgsspfhehaevvftandsgprrytiaallspysystta
vvtnpke
Sequence, based on observed residues (ATOM records): (download)
>4i87A (A:)
cplmvkvldavrgspainvavhvfrkaaddtwepfasgktsesgelhgltteeefvegiy
kveidtksywkalgsspfhehaevvftandsgprrytiaallspysysttavvtnp
- Chain 'B':
Sequence, based on SEQRES records: (download)
>4i87B (B:)
gptgtgeskcplmvkvldavrgspainvavhvfrkaaddtwepfasgktsesgelhgltt
eeefvegiykveidtksywkalgsspfhehaevvftandsgprrytiaallspysystta
vvtnpke
Sequence, based on observed residues (ATOM records): (download)
>4i87B (B:)
cplmvkvldavrgspainvavhvfrkaaddtwepfasgktsesgelhgltteeefvegiy
kveidtksywkalgsspfhehaevvftandsgprrytiaallspysysttavvtn