PDB entry 4hva

View 4hva on RCSB PDB site
Description: Mechanistic and Structural Understanding of Uncompetitive Inhibitors of Caspase-6
Class: hydrolase/hydrolase inhibitor
Keywords: Caspase-6, active, VEID, uncompetitive inhibition, ternary complex, Caspase, protease, HYDROLASE-HYDROLASE INHIBITOR complex
Deposited on 2012-11-05, released 2013-03-20
The last revision prior to the SCOPe 2.02 freeze date was dated 2013-03-20, with a file datestamp of 2013-03-15.
Experiment type: XRAY
Resolution: 2.07 Å
R-factor: 0.174
AEROSPACI score: 0.46 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Caspase-6
    Species: Homo sapiens [TaxId:9606]
    Gene: CASP6, MCH2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.02: d4hvaa_
  • Chain 'B':
    Compound: Caspase-6
    Species: Homo sapiens [TaxId:9606]
    Gene: CASP6, MCH2
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: VEID Inhibitor
    Database cross-references and differences (RAF-indexed):
    • PDB 4HVA (0-4)
  • Chain 'D':
    Compound: VEID Inhibitor
    Database cross-references and differences (RAF-indexed):
    • PDB 4HVA (0-4)
  • Heterogens: 4HV, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4hvaA (A:)
afykremfdpaekykmdhrrrgialifnherffwhltlperrgtcadrdnltrrfsdlgf
evkcfndlkaeelllkihevstvshadadcfvcvflshgegnhiyaydakieiqtltglf
kgdkchslvgkpkifiiqacrgnqhdvpvipldvvdaasvytlpagadflmcysvaegyy
shretvngswyiqdlcemlgkygssleftelltlvnrkvsqrrvdfckdpsaigkkqvpc
fasmltkklhffpksngnshhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >4hvaA (A:)
fdpaekykmdhrrrgialifnherffwhltlperrgtcadrdnltrrfsdlgfevkcfnd
lkaeelllkihevstvshadadcfvcvflshgegnhiyaydakieiqtltglfkgdkchs
lvgkpkifiiqacrgnqhdvpvipytlpagadflmcysvaegyyshretvngswyiqdlc
emlgkygssleftelltlvnrkvsqrrvdfckdpsaigkkqvpcfasmltkklhffpk

  • Chain 'B':
    No sequence available.

  • Chain 'C':
    No sequence available.

  • Chain 'D':
    No sequence available.