PDB entry 4hru

View 4hru on RCSB PDB site
Description: Molecular tweezers modulate 14-3-3 protein-protein interactions
Class: transferase inhibitor
Keywords: 14-3-3, Adaptor Protein, Protein-Protein Interaction, TRANSFERASE INHIBITOR
Deposited on 2012-10-28, released 2013-02-27
Made obsolete by 5oeg on 2017-07-26

The last revision prior to the SCOPe 2.04 freeze date was dated 2013-03-06, with a file datestamp of 2013-03-01.
Experiment type: XRAY
Resolution: 3.15 Å
R-factor: 0.194
AEROSPACI score: 0.24 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: 14-3-3 protein sigma
    Species: Homo sapiens [TaxId:9606]
    Gene: HME1, NM_006142, SFN
    Database cross-references and differences (RAF-indexed):
    • Uniprot P31947 (3-233)
      • expression tag (0-2)
    Domains in SCOPe 2.04: d4hrua_
  • Heterogens: 19O, CL, MG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4hruA (A:)
mgsmerasliqkaklaeqaeryedmaafmkgavekgeelsceernllsvayknvvggqra
awrvlssieqksneegseekgpevreyrekvetelqgvcdtvlglldshlikeagdaesr
vfylkmkgdyyrylaevatgddkkriidsarsayqeamdiskkempptnpirlglalnfs
vfhyeianspeeaislakttfdeamadlhtlsedsykdstlimqllrdnltlwt

    Sequence, based on observed residues (ATOM records): (download) 
    >4hruA (A:)
mgsmerasliqkaklaeqaeryedmaafmkgavekgeelsceernllsvayknvvggqra
awrvlssieqkgpevreyrekvetelqgvcdtvlglldshlieagdaesrvfylkmkgdy
yrylaevatgddkkriidsarsayqeamdiskkempptnpirlglalnfsvfhyeiansp
eeaislakttfdeamadlhtlsedsykdstlimqllrdnltlwt