PDB entry 4hiq

View 4hiq on RCSB PDB site
Description: The Structure of V122I Mutant Transthyretin in Complex with AG10
Class: hormone binding protein/inhibitor
Keywords: THYROID HORMONE TRANSPORT, Thyroxine, Retinol Binding Protein, HORMONE BINDING PROTEIN-INHIBITOR complex
Deposited on 2012-10-11, released 2013-06-05
The last revision prior to the SCOPe 2.07 freeze date was dated 2013-07-10, with a file datestamp of 2013-07-05.
Experiment type: XRAY
Resolution: 1.18 Å
R-factor: 0.161
AEROSPACI score: 0.84 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Transthyretin
    Species: Homo sapiens [TaxId:9606]
    Gene: PALB, TTR
    Database cross-references and differences (RAF-indexed):
    • Uniprot P02766
      • engineered mutation (121)
    Domains in SCOPe 2.07: d4hiqa_
  • Chain 'B':
    Compound: Transthyretin
    Species: Homo sapiens [TaxId:9606]
    Gene: PALB, TTR
    Database cross-references and differences (RAF-indexed):
    • Uniprot P02766
      • engineered mutation (121)
    Domains in SCOPe 2.07: d4hiqb_
  • Heterogens: 16V, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4hiqA (A:)
gptgtgeskcplmvkvldavrgspainvavhvfrkaaddtwepfasgktsesgelhgltt
eeefvegiykveidtksywkalgispfhehaevvftandsgprrytiaallspysystta
vitnpke

    Sequence, based on observed residues (ATOM records): (download) 
    >4hiqA (A:)
cplmvkvldavrgspainvavhvfrkaaddtwepfasgktsesgelhgltteeefvegiy
kveidtksywkalgispfhehaevvftandsgprrytiaallspysysttavitnp

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4hiqB (B:)
gptgtgeskcplmvkvldavrgspainvavhvfrkaaddtwepfasgktsesgelhgltt
eeefvegiykveidtksywkalgispfhehaevvftandsgprrytiaallspysystta
vitnpke

    Sequence, based on observed residues (ATOM records): (download) 
    >4hiqB (B:)
cplmvkvldavrgspainvavhvfrkaaddtwepfasgktsesgelhgltteeefvegiy
kveidtksywkalgispfhehaevvftandsgprrytiaallspysysttavitn