PDB entry 4he2

View 4he2 on RCSB PDB site
Description: Crystal structure of human muscle fructose-1,6-bisphosphatase Q32R mutant complex with AMP
Class: hydrolase
Keywords: allosteric enzyme, HYDROLASE
Deposited on 2012-10-03, released 2013-10-09
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-11-15, with a file datestamp of 2017-11-10.
Experiment type: XRAY
Resolution: 1.6 Å
R-factor: N/A
AEROSPACI score: 0.44 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Fructose-1,6-bisphosphatase isozyme 2
    Species: Homo sapiens [TaxId:9606]
    Gene: FBP2
    Database cross-references and differences (RAF-indexed):
    • Uniprot O00757
      • engineered mutation (31)
      • conflict (84)
    Domains in SCOPe 2.07: d4he2a_
  • Heterogens: AMP, PO3, MG, ZN, CL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4he2A (A:)
tdrspfetdmltltryvmekgrqakgtgeltrllnsmltaikaissavrkaglahlygia
gsvnvtgdevkkldvlsnslvinmlqssystcvlvseenkdaiitakekrgkyvvcfdpl
dgssnidclasigtifaiyrktsedepsekdalqcgrnivaagyalygsatlvalstgqg
vdlfmldpalgefvlvekdvkikkkgkiyslnegyakyfdaatteyvqkkkfpedgsapy
garyvgsmvadvhrtlvyggiflypanqkspkgklrllyecnpvayiieqagglattgtq
pvldvkpeaihqrvplilgspedvqeyltcvqknqags

    Sequence, based on observed residues (ATOM records): (download) 
    >4he2A (A:)
ltltryvmekgrqakgtgeltrllnsmltaikaissavrkaglakldvlsnslvinmlqs
systcvlvseenkdaiitakekrgkyvvcfdpldgssnidclasigtifaiyrktsedep
sekdalqcgrnivaagyalygsatlvalstgqgvdlfmldpalgefvlvekdvkikkkgk
iyslnegyakyfdaatteyvqkkkfpedgsapygaryvgsmvadvhrtlvyggiflypan
qkspkgklrllyecnpvayiieqagglattgtqpvldvkpeaihqrvplilgspedvqey
ltcvqknq