PDB entry 4gtl

View 4gtl on RCSB PDB site
Description: T. Maritima FDTS (R174K mutant) with FAD
Class: transferase
Keywords: Flavin-dependent thymidylate synthase, TM0449, R174K mutant, FAD, TRANSFERASE
Deposited on 2012-08-28, released 2012-10-17
The last revision prior to the SCOPe 2.04 freeze date was dated 2012-10-17, with a file datestamp of 2012-10-12.
Experiment type: XRAY
Resolution: 2.17 Å
R-factor: 0.192
AEROSPACI score: 0.39 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Thymidylate synthase thyX
    Species: Thermotoga maritima [TaxId:243274]
    Gene: thyX, thy1, TM_0449
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9WYT0 (12-End)
      • expression tag (9-11)
      • engineered mutation (185)
    Domains in SCOPe 2.04: d4gtla_
  • Chain 'B':
    Compound: Thymidylate synthase thyX
    Species: Thermotoga maritima [TaxId:243274]
    Gene: thyX, thy1, TM_0449
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9WYT0 (12-End)
      • expression tag (11)
      • engineered mutation (185)
    Domains in SCOPe 2.04: d4gtlb_
  • Chain 'C':
    Compound: Thymidylate synthase thyX
    Species: Thermotoga maritima [TaxId:243274]
    Gene: thyX, thy1, TM_0449
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9WYT0 (12-231)
      • expression tag (11)
      • engineered mutation (185)
    Domains in SCOPe 2.04: d4gtlc_
  • Chain 'D':
    Compound: Thymidylate synthase thyX
    Species: Thermotoga maritima [TaxId:243274]
    Gene: thyX, thy1, TM_0449
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9WYT0 (12-End)
      • expression tag (11)
      • engineered mutation (185)
    Domains in SCOPe 2.04: d4gtld_
  • Heterogens: FAD, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4gtlA (A:)
mgsdkihhhhhhmkidildkgfvelvdvmgndlsavraarvsfdmglkdeerdrhlieyl
mkhghetpfehivftfhvkapifvarqwfrhriasynelsgrysklsyefyipsperleg
ykttippervtekiseivdkayrtyleliesgvprevarivlplnlytrffwtvnarslm
nflnlkadshaqweiqqyalaiarifkekcpwtfeaflkyaykgdilkevqv

    Sequence, based on observed residues (ATOM records): (download) 
    >4gtlA (A:)
hhhmkidildkgfvelvdvmgndlsavraarvsfdmdeerdrhlieylmkhghetpfehi
vftfhvkapifvarqwfrhriasynelsrysklsyefyipsperlegykttippervtek
iseivdkayrtyleliesgvprevarivlplnlytrffwtvnarslmnflnlkadshaqw
eiqqyalaiarifkekcpwtfeaflkyaykgdilke

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4gtlB (B:)
mgsdkihhhhhhmkidildkgfvelvdvmgndlsavraarvsfdmglkdeerdrhlieyl
mkhghetpfehivftfhvkapifvarqwfrhriasynelsgrysklsyefyipsperleg
ykttippervtekiseivdkayrtyleliesgvprevarivlplnlytrffwtvnarslm
nflnlkadshaqweiqqyalaiarifkekcpwtfeaflkyaykgdilkevqv

    Sequence, based on observed residues (ATOM records): (download) 
    >4gtlB (B:)
hmkidildkgfvelvdvmgndlsavraarvsfdeerdrhlieylmkhghetpfehivftf
hvkapifvarqwfrhriasynelsgrysklsyefyipsperlegykttippervtekise
ivdkayrtyleliesgvprevarivlplnlytrffwtvnarslmnflnlkadshaqweiq
qyalaiarifkekcpwtfeaflkyaykgdilkevq

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >4gtlC (C:)
mgsdkihhhhhhmkidildkgfvelvdvmgndlsavraarvsfdmglkdeerdrhlieyl
mkhghetpfehivftfhvkapifvarqwfrhriasynelsgrysklsyefyipsperleg
ykttippervtekiseivdkayrtyleliesgvprevarivlplnlytrffwtvnarslm
nflnlkadshaqweiqqyalaiarifkekcpwtfeaflkyaykgdilkevqv

    Sequence, based on observed residues (ATOM records): (download) 
    >4gtlC (C:)
hmkidildkgfvelvdvmgndlsavraarvsfdkdeerdrhlieylmkhghetpfehivf
tfhvkapifvarqwfrhriasynelslsyefyipsperlegykttippervtekiseivd
kayrtyleliesgvprevarivlplnlytrffwtvnarslmnflnlkadshaqweiqqya
laiarifkekcpwtfeaflkyaykgdilkevqv

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >4gtlD (D:)
mgsdkihhhhhhmkidildkgfvelvdvmgndlsavraarvsfdmglkdeerdrhlieyl
mkhghetpfehivftfhvkapifvarqwfrhriasynelsgrysklsyefyipsperleg
ykttippervtekiseivdkayrtyleliesgvprevarivlplnlytrffwtvnarslm
nflnlkadshaqweiqqyalaiarifkekcpwtfeaflkyaykgdilkevqv

    Sequence, based on observed residues (ATOM records): (download) 
    >4gtlD (D:)
hmkidildkgfvelvdvmgndlsavraarvsfdkdeerdrhlieylmkhghetpfehivf
tfhvkapifvarqwfrhriasynelsgrysklsyefyipsperlegykttippervteki
seivdkayrtyleliesgvprevarivlplnlytrffwtvnarslmnflnlkadshaqwe
iqqyalaiarifkekcpwtfeaflkyaykgdilkev