PDB entry 4gtf

View 4gtf on RCSB PDB site
Description: T. Maritima FDTS (H53A mutant) with FAD, dUMP and Folate
Class: transferase
Keywords: Flavin-dependent thymidylate synthase, TM0449, H53A mutant, FAD, 5,10-Methylenetetrahydrofolate, dUMP, TRANSFERASE
Deposited on 2012-08-28, released 2012-10-17
The last revision prior to the SCOPe 2.06 freeze date was dated 2012-10-17, with a file datestamp of 2012-10-12.
Experiment type: XRAY
Resolution: 1.77 Å
R-factor: 0.163
AEROSPACI score: 0.57 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Thymidylate synthase thyX
    Species: Thermotoga maritima [TaxId:243274]
    Gene: thyX, thy1, TM_0449
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9WYT0 (12-End)
      • engineered mutation (64)
    Domains in SCOPe 2.06: d4gtfa_
  • Heterogens: FAD, UMP, MEF, CL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4gtfA (A:)
mgsdkihhhhhhmkidildkgfvelvdvmgndlsavraarvsfdmglkdeerdrhlieyl
mkhgaetpfehivftfhvkapifvarqwfrhriasynelsgrysklsyefyipsperleg
ykttippervtekiseivdkayrtyleliesgvprevarivlplnlytrffwtvnarslm
nflnlradshaqweiqqyalaiarifkekcpwtfeaflkyaykgdilkevqv

    Sequence, based on observed residues (ATOM records): (download) 
    >4gtfA (A:)
mkidildkgfvelvdvmgndlsavraarvsfdmkdeerdrhlieylmkhgaetpfehivf
tfhvkapifvarqwfrhriasynelsgrysklsyefyipsperlegykttippervteki
seivdkayrtyleliesgvprevarivlplnlytrffwtvnarslmnflnlradshaqwe
iqqyalaiarifkekcpwtfeaflkyaykgdil