PDB entry 4gov

View 4gov on RCSB PDB site
Description: The crystal structure of human fascin 1 S39D mutant
Class: protein binding
Keywords: beta-trefoil, actin bundling protein, cancer, metastasis, cell migration, Actin-binding, Phosphoprotein, PROTEIN BINDING, Actin
Deposited on 2012-08-20, released 2012-11-28
The last revision prior to the SCOPe 2.07 freeze date was dated 2013-01-30, with a file datestamp of 2013-01-25.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: 0.198
AEROSPACI score: 0.4 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: fascin
    Species: Homo sapiens [TaxId:9606]
    Gene: FAN1, FSCN1, HSN, SNL
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q16658 (Start-492)
      • engineered mutation (38)
    Domains in SCOPe 2.07: d4gova1, d4gova2, d4gova3, d4gova4
  • Chain 'B':
    Compound: fascin
    Species: Homo sapiens [TaxId:9606]
    Gene: FAN1, FSCN1, HSN, SNL
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q16658 (Start-492)
      • engineered mutation (38)
    Domains in SCOPe 2.07: d4govb1, d4govb2, d4govb3, d4govb4
  • Heterogens: BR, CL, GOL, DTT, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4govA (A:)
mtangtaeavqiqfglincgnkyltaeafgfkvnasasdlkkkqiwtleqppdeagsaav
clrshlgrylaadkdgnvtcerevpgpdcrflivahddgrwslqseahrryfggtedrls
cfaqtvspaekwsvhiamhpqvniysvtrkryahlsarpadeiavdrdvpwgvdslitla
fqdqrysvqtadhrflrhdgrlvarpepatgytlefrsgkvafrdcegrylapsgpsgtl
kagkatkvgkdelfaleqscaqvvlqaanernvstrqgmdlsanqdeetdqetfqleidr
dtkkcafrthtgkywtltatggvqstassknascyfdiewrdrritlrasngkfvtskkn
gqlaasvetagdselflmklinrpiivfrgehgfigcrkvtgtldanrssydvfqlefnd
gaynikdstgkywtvgsdsavtssgdtpvdfffefcdynkvaikvggrylkgdhagvlka
saetvdpaslwey

    Sequence, based on observed residues (ATOM records): (download) 
    >4govA (A:)
taeavqiqfglincgnkyltaeafgfkvnasasdlkkkqiwtleqppagsaavclrshlg
rylaadkdgnvtcerevpgpdcrflivahddgrwslqseahrryfggtedrlscfaqtvs
paekwsvhiamhpqvniysvtrkryahlspadeiavdrdvpwgvdslitlafqdqrysvq
tadhrflrhdgrlvarpepatgytlefrsgkvafrdcegrylapsgpsgtlkagvgkdel
faleqscaqvvlqaanernvstmdlsanqdeetdqetfqleidrkcafrthtgkywtlta
tggvqstasskscyfdiewrdrritlrasngkfvtskkngqlaasvetagdselflmkli
nrpiivfrgehgfigcrtgtldanrssydvfqlefndgaynikdstgkywtvgsdsavts
sgdtpvdfffefcdynkvaikvggrylkgdhagvlkasaetvdpaslwey

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4govB (B:)
mtangtaeavqiqfglincgnkyltaeafgfkvnasasdlkkkqiwtleqppdeagsaav
clrshlgrylaadkdgnvtcerevpgpdcrflivahddgrwslqseahrryfggtedrls
cfaqtvspaekwsvhiamhpqvniysvtrkryahlsarpadeiavdrdvpwgvdslitla
fqdqrysvqtadhrflrhdgrlvarpepatgytlefrsgkvafrdcegrylapsgpsgtl
kagkatkvgkdelfaleqscaqvvlqaanernvstrqgmdlsanqdeetdqetfqleidr
dtkkcafrthtgkywtltatggvqstassknascyfdiewrdrritlrasngkfvtskkn
gqlaasvetagdselflmklinrpiivfrgehgfigcrkvtgtldanrssydvfqlefnd
gaynikdstgkywtvgsdsavtssgdtpvdfffefcdynkvaikvggrylkgdhagvlka
saetvdpaslwey

    Sequence, based on observed residues (ATOM records): (download) 
    >4govB (B:)
aeavqiqfglincgnkyltaeafgfkvnasasdlkkkqiwtleqppdaavclrshlgryl
aadkdgnvtcerevpgpdcrflivahddgrwslqseahrryfggtedrlscfaqtvspae
kwsvhiamhpqvniysvtrkryahlsarpadeiavdrdvpwgvdslitlafqdqrysvqt
adhrflrhdgrlvarpepatgytlefrsgkvafrdcegrylapsgpsgtlkagkatkvgk
delfaleqscaqvvlqaanernvstrqgmdlsanqdeetdqetfqleidrdtkkcafrth
tgkywtltatggvqstassknascyfdiewrdrritlrasngkfvtskkngqlaasveta
gdselflmklinrpiivfrgehgfigcrkvtgtldanrssydvfqlefndgaynikdstg
kywtvgsdsavtssgdtpvdfffefcdynkvaikvggrylkgdhagvlkasaetvdpasl
wey