PDB entry 4gaf

View 4gaf on RCSB PDB site
Description: Crystal structure of EBI-005, a chimera of human IL-1beta and IL-1Ra, bound to human Interleukin-1 receptor type 1
Class: signaling protein
Keywords: IL-1beta, IL-1Ra, IL-1R1, IL-1 signaling, Beta-trefoil, SIGNALING PROTEIN
Deposited on 2012-07-25, released 2013-02-20
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-07-29, with a file datestamp of 2020-07-04.
Experiment type: XRAY
Resolution: 2.15 Å
R-factor: N/A
AEROSPACI score: 0.33 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: ebi-005
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 4GAF (0-End)
    Domains in SCOPe 2.08: d4gafa_
  • Chain 'B':
    Compound: Interleukin-1 receptor type 1
    Species: Homo sapiens [TaxId:9606]
    Gene: IL1R1, IL1R, IL1RA, IL1RT1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4gafb1, d4gafb2, d4gafb3
  • Heterogens: NAG, NA, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4gafA (A:)
apvrslncriwdvnqktfylrnnqlvagylqgpnvnleekfsmsfvqgeesndkipvalg
lkeknlylscvlkddkptlqlesvdpknypkkkmekrfvfnkieinnklefesaqfpnwf
lctameadqpvsltnmpdegvmvtkfymqfvss

    Sequence, based on observed residues (ATOM records): (download) 
    >4gafA (A:)
apvrslncriwdvnqktfylrnnqlvagylqgpnvnleekfsmsfvqgeesndkipvalg
lkeknlylscvlkddkptlqlesvdpknypkkkmekrfvfnkieinnklefesaqfpnwf
lctameadqpvsltnmpdegvmvtkfymqfvs

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4gafB (B:)
leadkckereekiilvssaneidvrpcplnpnehkgtitwykddsktpvsteqasrihqh
keklwfvpakvedsghyycvvrnssyclrikisakfvenepnlcynaqaifkqklpvagd
gglvcpymeffknennelpklqwykdckpllldnihfsgvkdrlivmnvaekhrgnytch
asytylgkqypitrviefitleenkptrpvivspanetmevdlgsqiqlicnvtgqlsdi
aywkwngsvideddpvlgedyysvenpankrrstlitvlniseiesrfykhpftcfaknt
hgidaayiqliypvtnfqk

    Sequence, based on observed residues (ATOM records): (download) 
    >4gafB (B:)
dkckereekiilvssaneidvrpcplnpnehkgtitwykddsktpvsteqasrihqhkek
lwfvpakvedsghyycvvyclrikisakfvenepnlcynaqaifkqklpvagdgglvcpy
meffknennelpklqwykdckpllldnihfsgvkdrlivmnvaekhrgnytchasytylg
kqypitrviefitleenkptrpvivspanetmevdlgsqiqlicnvtgqlsdiaywkwng
svideddpvlgedyysvenpankrrstlitvlniseiesrfykhpftcfaknthgidaay
iqliyp