PDB entry 4g2o

View 4g2o on RCSB PDB site
Description: Human Thymidylate Synthase M190K with bound Purpurogallin
Class: transferase/transferase inhibitor
Keywords: Methyltransferase, Transferase, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on 2012-07-12, released 2013-07-17
The last revision prior to the SCOPe 2.06 freeze date was dated 2014-11-19, with a file datestamp of 2014-11-14.
Experiment type: XRAY
Resolution: 2.25 Å
R-factor: 0.225
AEROSPACI score: 0.27 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'X':
    Compound: Thymidylate synthase
    Species: Homo sapiens [TaxId:9606]
    Gene: OK/SW-cl.29, TS, TYMS
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04818
      • engineered mutation (189)
    Domains in SCOPe 2.06: d4g2ox_
  • Heterogens: TIY, SO4, HOH

PDB Chain Sequences:

  • Chain 'X':
    Sequence, based on SEQRES records: (download) 
    >4g2oX (X:)
mpvagselprrplppaaqerdaeprpphgelqylgqiqhilrcgvrkddrtgtgtlsvfg
mqaryslrdefpllttkrvfwkgvleellwfikgstnakelsskgvkiwdangsrdflds
lgfstreegdlgpvygfqwrhfgaeyrdmesdysgqgvdqlqrvidtiktnpddrriimc
awnprdlplkalppchalcqfyvvnselscqlyqrsgdmglgvpfniasyalltymiahi
tglkpgdfihtlgdahiylnhieplkiqlqreprpfpklrilrkvekiddfkaedfqieg
ynphptikmemav

    Sequence, based on observed residues (ATOM records): (download) 
    >4g2oX (X:)
phgelqylgqiqhilrcgvrkddrtgtgtlsvfgmqaryslrdefpllttkrvfwkgvle
ellwfikgstnakelsskgvldslgfstreegdlgpvygfqwrhfgaeyrdmesdysgqg
vdqlqrvidtiktnpddrriimcawnprdlplkalppchalcqfyvvnselscqlyqrsg
dmglgvpfniasyalltymiahitglkpgdfihtlgdahiylnhieplkiqlqreprpfp
klrilrkvekiddfkaedfqiegynphptikme