PDB entry 4ffx

View 4ffx on RCSB PDB site
Description: Structural and Biochemical Characterization of Human Adenylosuccinate Lyase (ADSL) and the R303C ADSL Deficiency Associated Mutation
Class: lyase
Keywords: purine biosynthesis, lyase, disease mutation, purine metabolism
Deposited on 2012-06-01, released 2012-08-01
The last revision prior to the SCOPe 2.05 freeze date was dated 2012-09-12, with a file datestamp of 2012-09-07.
Experiment type: XRAY
Resolution: 2.7 Å
R-factor: 0.245
AEROSPACI score: 0.25 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: adenylosuccinate lyase
    Species: Homo sapiens [TaxId:9606]
    Gene: ADSL, AMPS
    Database cross-references and differences (RAF-indexed):
    • Uniprot P30566
      • conflict (65)
    Domains in SCOPe 2.05: d4ffxa_
  • Chain 'B':
    Compound: adenylosuccinate lyase
    Species: Homo sapiens [TaxId:9606]
    Gene: ADSL, AMPS
    Database cross-references and differences (RAF-indexed):
    • Uniprot P30566
      • conflict (65)
    Domains in SCOPe 2.05: d4ffxb_
  • Chain 'C':
    Compound: adenylosuccinate lyase
    Species: Homo sapiens [TaxId:9606]
    Gene: ADSL, AMPS
    Database cross-references and differences (RAF-indexed):
    • Uniprot P30566
      • conflict (65)
    Domains in SCOPe 2.05: d4ffxc_
  • Chain 'D':
    Compound: adenylosuccinate lyase
    Species: Homo sapiens [TaxId:9606]
    Gene: ADSL, AMPS
    Database cross-references and differences (RAF-indexed):
    • Uniprot P30566
      • conflict (65)
    Domains in SCOPe 2.05: d4ffxd_
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4ffxA (A:)
gshmaaggdhgspdsyrsplasryaspemcfvfsdrykfrtwrqlwlwlaeaeqtlglpi
tdeqiremksnlenidfkmaaeeekrlrhdvmahvhtfghccpkaagiihlgatscyvgd
ntdliilrnaldlllpklarvisrladfakeraslptlgfthfqpaqlttvgkrcclwiq
dlcmdlqnlkrvrddlrfrgvkgttgtqasflqlfegddhkveqldkmvtekagfkrafi
itgqtytrkvdievlsvlaslgasvhkictdirllanlkemeepfekqqigssampykrn
pmrserccslarhlmtlvmdplqtasvqwfertlddsanrriclaeafltadtilntlqn
iseglvvypkvierrirqelpfmateniimamvkaggsrqdchekirvlsqqaasvvkqe
ggdndlieriqvdayfspihsqldhlldpssftgrasqqvqrfleeevypllkpyesvmk
vkaelcl

    Sequence, based on observed residues (ATOM records): (download) 
    >4ffxA (A:)
dhgspdsyrsplasryaspemcfvfsdrykfrtwrqlwlwlaeaeqtlglpitdeqirem
ksnlenidfkmaaeeekrlrhdvmahvhtfghccpkaagiihlgatscyvgdntdliilr
naldlllpklarvisrladfakeraslptlgfthfqpaqlttvgkrcclwiqdlcmdlqn
lkrvrddlrfrgvkgttgtqasflqlfegddhkveqldkmvtekagfkrafiitgqtytr
kvdievlsvlaslgasvhkictdirllanlkemeepfkrnpmrserccslarhlmtlvmd
plqtasvqwfertlddsanrriclaeafltadtilntlqniseglvvypkvierrirqel
pfmateniimamvkaggsrqdchekirvlsqqaasvvkqeggdndlieriqvdayfspih
sqldhlldpssftgrasqqvqrfleeevypllkpyes

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4ffxB (B:)
gshmaaggdhgspdsyrsplasryaspemcfvfsdrykfrtwrqlwlwlaeaeqtlglpi
tdeqiremksnlenidfkmaaeeekrlrhdvmahvhtfghccpkaagiihlgatscyvgd
ntdliilrnaldlllpklarvisrladfakeraslptlgfthfqpaqlttvgkrcclwiq
dlcmdlqnlkrvrddlrfrgvkgttgtqasflqlfegddhkveqldkmvtekagfkrafi
itgqtytrkvdievlsvlaslgasvhkictdirllanlkemeepfekqqigssampykrn
pmrserccslarhlmtlvmdplqtasvqwfertlddsanrriclaeafltadtilntlqn
iseglvvypkvierrirqelpfmateniimamvkaggsrqdchekirvlsqqaasvvkqe
ggdndlieriqvdayfspihsqldhlldpssftgrasqqvqrfleeevypllkpyesvmk
vkaelcl

    Sequence, based on observed residues (ATOM records): (download) 
    >4ffxB (B:)
gspdsyrsplasryaspemcfvfsdrykfrtwrqlwlwlaeaeqtlglpitdeqiremks
nlenidfkmaaeeekrlrhdvmahvhtfghccaagiihlgatscyvgdntdliilrnald
lllpklarvisrladfakeraslptlgfthfqpaqlttvgkrcclwiqdlcmdlqnlkrv
rddlrfrgvkgttgtqasflqlfegddhkveqldkmvtekagfkrafiitgqtytrkvdi
evlsvlaslgasvhkictdirllanlkemeepfepykrnpmrserccslarhlmtlvmdp
lqtasvqwfertlddsanrriclaeafltadtilntlqniseglvvypkvierrirqelp
fmateniimamvkaggsrqdchekirvlsqqaasvvkqeggdndlieriqvdayfspihs
qldhlldpssftgrasqqvqrfleeevypllkpyes

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >4ffxC (C:)
gshmaaggdhgspdsyrsplasryaspemcfvfsdrykfrtwrqlwlwlaeaeqtlglpi
tdeqiremksnlenidfkmaaeeekrlrhdvmahvhtfghccpkaagiihlgatscyvgd
ntdliilrnaldlllpklarvisrladfakeraslptlgfthfqpaqlttvgkrcclwiq
dlcmdlqnlkrvrddlrfrgvkgttgtqasflqlfegddhkveqldkmvtekagfkrafi
itgqtytrkvdievlsvlaslgasvhkictdirllanlkemeepfekqqigssampykrn
pmrserccslarhlmtlvmdplqtasvqwfertlddsanrriclaeafltadtilntlqn
iseglvvypkvierrirqelpfmateniimamvkaggsrqdchekirvlsqqaasvvkqe
ggdndlieriqvdayfspihsqldhlldpssftgrasqqvqrfleeevypllkpyesvmk
vkaelcl

    Sequence, based on observed residues (ATOM records): (download) 
    >4ffxC (C:)
gspdsyrsplasryaspemcfvfsdrykfrtwrqlwlwlaeaeqtlglpitdeqiremks
nlenidfkmaaeeekrlrhdvmahvhtfghccpkaagiihlgatscyvgdntdliilrna
ldlllpklarvisrladfakeraslptlgfthfqpaqlttvgkrcclwiqdlcmdlqnlk
rvrddlrfrgvkgttgtqasflqlfegddhkveqldkmvtekagfkrafiitgqtytrkv
dievlsvlaslgasvhkictdirllanlkemeepfnpmrserccslarhlmtlvmdplqt
asvqwfertlddsanrriclaeafltadtilntlqniseglvvypkvierrirqelpfma
teniimamvkaggsrqdchekirvlsqqaasvvkqeggdndlieriqvdayfspihsqld
hlldpssftgrasqqvqrfleeevypllkpy

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >4ffxD (D:)
gshmaaggdhgspdsyrsplasryaspemcfvfsdrykfrtwrqlwlwlaeaeqtlglpi
tdeqiremksnlenidfkmaaeeekrlrhdvmahvhtfghccpkaagiihlgatscyvgd
ntdliilrnaldlllpklarvisrladfakeraslptlgfthfqpaqlttvgkrcclwiq
dlcmdlqnlkrvrddlrfrgvkgttgtqasflqlfegddhkveqldkmvtekagfkrafi
itgqtytrkvdievlsvlaslgasvhkictdirllanlkemeepfekqqigssampykrn
pmrserccslarhlmtlvmdplqtasvqwfertlddsanrriclaeafltadtilntlqn
iseglvvypkvierrirqelpfmateniimamvkaggsrqdchekirvlsqqaasvvkqe
ggdndlieriqvdayfspihsqldhlldpssftgrasqqvqrfleeevypllkpyesvmk
vkaelcl

    Sequence, based on observed residues (ATOM records): (download) 
    >4ffxD (D:)
gdhgspdsyrsplasryaspemcfvfsdrykfrtwrqlwlwlaeaeqtlglpitdiremk
snlenidfkmaaeeekrldvmahvhtfghccpkaagiihlgatscyvgdntdliilrnal
dlllpklarvisrladfakeraslptlgfthfqpaqlttvgkrcclwiqdlcmdlqnlkr
vrddlrfrgvkgttgtqasflqlfegddhkveqldkmvtekagfkrafiitgqtytrkvd
ievlsvlaslgasvhkictdirllanlkemeepfepykrnpmrserccslarhlmtlvmd
plqtasvqwfertlddsanrriclaeafltadtilntlqniseglvvypkvierrirqel
pfmateniimamvkaggsrqdchekirvlsqqaasvvkqeggdndlieriqvdayfspih
sqldhlldpssftgrasqqvqrfleeevypllkpye