PDB entry 4ey8

View 4ey8 on RCSB PDB site
Description: Crystal structure of recombinant human acetylcholinesterase in complex with fasciculin-2
Class: hydrolase/hydrolase inhibitor
Keywords: acetylcholinesterase, hydrolase, fasciculin 2, snake venom toxin, inhibitor, HYDROLASE-HYDROLASE INHIBITOR complex
Deposited on 2012-05-01, released 2012-10-17
The last revision prior to the SCOPe 2.06 freeze date was dated 2012-12-12, with a file datestamp of 2012-12-07.
Experiment type: XRAY
Resolution: 2.6 Å
R-factor: 0.196
AEROSPACI score: 0.31 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: acetylcholinesterase
    Species: Homo sapiens [TaxId:9606]
    Gene: ACHE
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d4ey8a_
  • Chain 'B':
    Compound: fasciculin-2
    Species: Dendroaspis angusticeps [TaxId:8618]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d4ey8b_
  • Heterogens: SO4, NAG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4ey8A (A:)
gredaellvtvrggrlrgirlktpggpvsaflgipfaeppmgprrflppepkqpwsgvvd
attfqsvcyqyvdtlypgfegtemwnpnrelsedclylnvwtpyprptsptpvlvwiygg
gfysgassldvydgrflvqaertvlvsmnyrvgafgflalpgsreapgnvglldqrlalq
wvqenvaafggdptsvtlfgesagaasvgmhllsppsrglfhravlqsgapngpwatvgm
gearrratqlahlvgcppggtggndtelvaclrtrpaqvlvnhewhvlpqesvfrfsfvp
vvdgdflsdtpealinagdfhglqvlvgvvkdegsyflvygapgfskdneslisraefla
gvrvgvpqvsdlaaeavvlhytdwlhpedparlrealsdvvgdhnvvcpvaqlagrlaaq
garvyayvfehrastlswplwmgvphgyeiefifgipldpsrnytaeekifaqrlmrywa
nfartgdpneprdpkapqwppytagaqqyvsldlrplevrrglraqacafwnrflpklls
at

    Sequence, based on observed residues (ATOM records): (download) 
    >4ey8A (A:)
daellvtvrggrlrgirlktpggpvsaflgipfaeppmgprrflppepkqpwsgvvdatt
fqsvcyqyvdtlypgfegtemwnpnrelsedclylnvwtpyprptsptpvlvwiygggfy
sgassldvydgrflvqaertvlvsmnyrvgafgflalpgsreapgnvglldqrlalqwvq
envaafggdptsvtlfgesagaasvgmhllsppsrglfhravlqsgapngpwatvgmgea
rrratqlahlvgcpndtelvaclrtrpaqvlvnhewhvlpqesvfrfsfvpvvdgdflsd
tpealinagdfhglqvlvgvvkdegsyflvygapgfskdneslisraeflagvrvgvpqv
sdlaaeavvlhytdwlhpedparlrealsdvvgdhnvvcpvaqlagrlaaqgarvyayvf
ehrastlswplwmgvphgyeiefifgipldpsrnytaeekifaqrlmrywanfartgdpn
eprdpqwppytagaqqyvsldlrplevrrglraqacafwnrflpkllsat

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4ey8B (B:)
tmcyshtttsrailtncgenscyrksrrhppkmvlgrgcgcppgddnlevkcctspdkcn
y