PDB entry 4eaw

View 4eaw on RCSB PDB site
Description: HCV NS5B in complex with IDX375
Class: transferase/transferase inhibitor
Keywords: TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on 2012-03-22, released 2013-03-27
The last revision prior to the SCOPe 2.06 freeze date was dated 2013-03-27, with a file datestamp of 2013-03-22.
Experiment type: XRAY
Resolution: 2 Å
R-factor: 0.173
AEROSPACI score: 0.48 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: RNA-directed RNA polymerase
    Species: Hepatitis C virus subtype 1b [TaxId:31647]
    Database cross-references and differences (RAF-indexed):
    • Uniprot O92972 (0-561)
      • conflict (315)
    Domains in SCOPe 2.06: d4eawa_
  • Chain 'B':
    Compound: RNA-directed RNA polymerase
    Species: Hepatitis C virus subtype 1b [TaxId:31647]
    Database cross-references and differences (RAF-indexed):
    • Uniprot O92972 (0-561)
      • conflict (315)
    Domains in SCOPe 2.06: d4eawb_
  • Heterogens: 0NQ, SO4, PEG, EDO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4eawA (A:)
smsytwtgalitpcaaeesklpinplsnsllrhhnmvyattsrsaslrqkkvtfdrlqvl
ddhyrdvlkemkakastvkakllsieeackltpphsakskfgygakdvrnlssravnhir
svwedlledtetpidttimaksevfcvqpekggrkparlivfpdlgvrvcekmalydvvs
tlpqavmgssygfqyspkqrveflvntwkskkcpmgfsydtrcfdstvtesdirveesiy
qccdlapearqairslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylkat
aacraaklqdctmlvygddlvvicesagtqedaaalrafteamtrysappgdppqpeydl
elitscssnvsvahdasgkrvyyltrdpttplaraawetarhtpinswlgniimyaptlw
armilmthffsillaqeqlekaldcqiygacysiepldlpqiierlhglsaftlhsyspg
einrvasclrklgvpplrtwrhrarsvrakllsqggraatcgrylfnwavrtklkltpip
aasqldlsgwfvagysggdiyh

    Sequence, based on observed residues (ATOM records): (download) 
    >4eawA (A:)
smsytwtgalitpcaaeesklpinplsnsllrhhnmvyattsrsaslrqkkvtfdrlqvl
ddhyrdvlkemkakastvkakllsieeackltpphsakskfgygakdvrnlssravnhir
svwedlledtetpidttimaksevfcvqpgrkparlivfpdlgvrvcekmalydvvstlp
qavmgssygfqyspkqrveflvntwkskkcpmgfsydtrcfdstvtesdirveesiyqcc
dlapearqairslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylkataac
raaklqdctmlvygddlvvicesagtqedaaalrafteamtrysappgdppqpeydleli
tscssnvsvahdasgkrvyyltrdpttplaraawetarhtpinswlgniimyaptlwarm
ilmthffsillaqeqlekaldcqiygacysiepldlpqiierlhglsaftlhsyspgein
rvasclrklgvpplrtwrhrarsvrakllsqggraatcgrylfnwavrtklkltpipaas
qldlsgwfvagysggdiyh

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4eawB (B:)
smsytwtgalitpcaaeesklpinplsnsllrhhnmvyattsrsaslrqkkvtfdrlqvl
ddhyrdvlkemkakastvkakllsieeackltpphsakskfgygakdvrnlssravnhir
svwedlledtetpidttimaksevfcvqpekggrkparlivfpdlgvrvcekmalydvvs
tlpqavmgssygfqyspkqrveflvntwkskkcpmgfsydtrcfdstvtesdirveesiy
qccdlapearqairslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylkat
aacraaklqdctmlvygddlvvicesagtqedaaalrafteamtrysappgdppqpeydl
elitscssnvsvahdasgkrvyyltrdpttplaraawetarhtpinswlgniimyaptlw
armilmthffsillaqeqlekaldcqiygacysiepldlpqiierlhglsaftlhsyspg
einrvasclrklgvpplrtwrhrarsvrakllsqggraatcgrylfnwavrtklkltpip
aasqldlsgwfvagysggdiyh

    Sequence, based on observed residues (ATOM records): (download) 
    >4eawB (B:)
smsytwtgalitpcaaeesklpinplsnsllrhhnmvyattsrsaslrqkkvtfdrlqvl
ddhyrdvlkemkakastvkakllsieeackltpphsakskfgygakdvrnlssravnhir
svwedlledtetpidttimaksevfcvqpgrkparlivfpdlgvrvcekmalydvvstlp
qavmgssygfqyspkqrveflvntwkskkcpmgfsydtrcfdstvtesdirveesiyqcc
dlapearqairslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylkataac
raaklqdctmlvygddlvvicesagtqedaaalrafteamtrysappgdppqpeydleli
tscssnvsvahdasgkrvyyltrdpttplaraawetarhtpinswlgniimyaptlwarm
ilmthffsillaqeqlekaldcqiygacysiepldlpqiierlhglsaftlhsyspgein
rvasclrklgvpplrtwrhrarsvrakllsqggraatcgrylfnwavrtklkltpipaas
qldlsgwfvagysggdiyh