PDB entry 4drh

View 4drh on RCSB PDB site
Description: Co-crystal structure of the PPIase domain of FKBP51, Rapamycin and the FRB fragment of mTOR at low pH
Class: Isomerase/Transferase
Keywords: Fk-506 binding domain, Hsp90 cochaperone, immunophilin, peptidyl-prolyl isomerase, mammalian target of Rapamycin, kinase, signalling, immunosuppression, cancer, Isomerase-Transferase complex
Deposited on 2012-02-17, released 2013-02-06
The last revision prior to the SCOPe 2.04 freeze date was dated 2013-03-27, with a file datestamp of 2013-03-22.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: 0.189
AEROSPACI score: 0.37 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Peptidyl-prolyl cis-trans isomerase FKBP5
    Species: Homo sapiens [TaxId:9606]
    Gene: AIG6, FKBP5, FKBP51
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d4drha_
  • Chain 'B':
    Compound: Serine/threonine-protein kinase mTOR
    Species: Homo sapiens [TaxId:9606]
    Gene: FRAP, FRAP1, FRAP2, MTOR, RAFT1, RAPT1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P42345 (8-End)
      • expression tag (1-7)
    Domains in SCOPe 2.04: d4drhb_
  • Chain 'D':
    Compound: Peptidyl-prolyl cis-trans isomerase FKBP5
    Species: Homo sapiens [TaxId:9606]
    Gene: AIG6, FKBP5, FKBP51
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d4drhd_
  • Chain 'E':
    Compound: Serine/threonine-protein kinase mTOR
    Species: Homo sapiens [TaxId:9606]
    Gene: FRAP, FRAP1, FRAP2, MTOR, RAFT1, RAPT1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P42345 (8-End)
      • expression tag (2-7)
    Domains in SCOPe 2.04: d4drhe_
  • Heterogens: RAP, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4drhA (A:)
gamgmttdegaknneesptatvaeqgeditskkdrgvlkivkrvgngeetpmigdkvyvh
ykgklsngkkfdsshdrnepfvfslgkgqvikawdigvatmkkgeichllckpeyaygsa
gslpkipsnatlffeielldfkge

    Sequence, based on observed residues (ATOM records): (download) 
    >4drhA (A:)
nneesptatvaeqgeditskkdrgvlkivkrvgngeetpmigdkvyvhykgklsngkkfd
sshdrnepfvfslgkgqvikawdigvatmkkgeichllckpeyaygsagslpkipsnatl
ffeielldfkge

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4drhB (B:)
gamdpefmemwhegleeasrlyfgernvkgmfevleplhammergpqtlketsfnqaygr
dlmeaqewcrkymksgnvkdltqawdlyyhvfrriskq

    Sequence, based on observed residues (ATOM records): (download) 
    >4drhB (B:)
amdpefmemwhegleeasrlyfgernvkgmfevleplhammergpqtlketsfnqaygrd
lmeaqewcrkymksgnvkdltqawdlyyhvfrris

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >4drhD (D:)
gamgmttdegaknneesptatvaeqgeditskkdrgvlkivkrvgngeetpmigdkvyvh
ykgklsngkkfdsshdrnepfvfslgkgqvikawdigvatmkkgeichllckpeyaygsa
gslpkipsnatlffeielldfkge

    Sequence, based on observed residues (ATOM records): (download) 
    >4drhD (D:)
neesptatvaeqgeditskkdrgvlkivkrvgngeetpmigdkvyvhykgklsngkkfds
shdrnepfvfslgkgqvikawdigvatmkkgeichllckpeyaygsagslpkipsnatlf
feielldfkge

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >4drhE (E:)
gamdpefmemwhegleeasrlyfgernvkgmfevleplhammergpqtlketsfnqaygr
dlmeaqewcrkymksgnvkdltqawdlyyhvfrriskq

    Sequence, based on observed residues (ATOM records): (download) 
    >4drhE (E:)
mdpefmemwhegleeasrlyfgernvkgmfevleplhammelketsfnqaygrdlmeaqe
wcrkymksgnvkdltqawdlyyhvfrris