PDB entry 4dk5

View 4dk5 on RCSB PDB site
Description: Crystal structure of human PI3K-gamma in complex with a pyridyl-triazine inhibitor
Class: Transferase/Inhibitor
Keywords: phosphotransferase, cancer, p85-alpha, p85-beta, Ras, Transferase-Inhibitor complex
Deposited on 2012-02-03, released 2012-05-16
The last revision prior to the SCOPe 2.07 freeze date was dated 2012-08-01, with a file datestamp of 2012-07-27.
Experiment type: XRAY
Resolution: 2.95 Å
R-factor: 0.224
AEROSPACI score: 0.23 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
    Species: Homo sapiens [TaxId:9606]
    Gene: PIK3CG
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d4dk5a1, d4dk5a2, d4dk5a3, d4dk5a4
  • Heterogens: SO4, 0KO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4dk5A (A:)
seesqafqrqltaligydvtdvsnvhddeleftrrglvtprmaevasrdpklyamhpwvt
skplpeylwkkianncifivihrsttsqtikvspddtpgailqsfftkmakkkslmdipe
sqseqdfvlrvcgrdeylvgetpiknfqwvrhclkngeeihvvldtppdpaldevrkeew
plvddctgvtgyheqltihgkdhesvftvslwdcdrkfrvkirgidipvlprntdltvfv
eaniqhgqqvlcqrrtspkpfteevlwnvwlefsikikdlpkgallnlqiycgkapalss
kasaespsseskgkvqllyyvnlllidhrfllrrgeyvlhmwqisgkgedqgsfnadklt
satnpdkensmsisilldnychpialpkhqptpdpegdrvraempnqlrkqleaiiatdp
lnpltaedkellwhfryeslkhpkaypklfssvkwgqqeivaktyqllarrevwdqsald
vgltmqlldcnfsdenvraiavqklesledddvlhyllqlvqavkfepyhdsalarfllk
rglrnkrighflfwflrseiaqsrhyqqrfavileaylrgcgtamlhdftqqvqviemlq
kvtldikslsaekydvssqvisqlkqklenlqnsqlpesfrvpydpglkagalaiekckv
maskkkplwlefkcadptalsnetigiifkhgddlrqdmlilqilrimesiwetesldlc
llpygcistgdkigmieivkdattiakiqqstvgntgafkdevlnhwlkekspteekfqa
averfvyscagycvatfvlgigdrhndnimitetgnlfhidfghilgnyksflginkerv
pfvltpdflfvmgtsgkktsphfqkfqdicvkaylalrhhtnlliilfsmmlmtgmpqlt
skedieyirdaltvgkneedakkyfldqievcrdkgwtvqfnwflhlvlgikqgekhsa

    Sequence, based on observed residues (ATOM records): (download) 
    >4dk5A (A:)
seesqafqrqltaligydvtdvsnvhddeleftrrglvtprmaevasrdpklyamhpwvt
skplpeylwkkianncifivihrsttsqtikvspddtpgailqsfftdfvlrvcgrdeyl
vgetpiknfqwvrhclkngeeihvvldtppdpaldevrkevslwdcdrkfrvkirgidip
vldltvfveaniqhgqqvlcqrrtspkpfteevlwnvwlefsikikdlpkgallnlqiyc
gkvqllyyvnlllidhrfllrrgeyvlhmwqissfnadkltsatnpdkensmsisilldn
pialpkhmpnqlrkqleaiiatdplnpltaedkellwhfryeslkhpkaypklfssvkwg
qqeivaktyqllarrevwdqsaldvgltmqlldcnfsdenvraiavqklesledddvlhy
llqlvqavkfepyhdsalarfllkrglrnkrighflfwflrseiaqsrhyqqrfavilea
ylrgcgtamlhdftqqvqviemlqkvtldikslsadvssqvisqlkqklenlqnsqlpes
frvpydpglkagalaiekckvmaskkkplwlefkcadptalsnetigiifkhgddlrqdm
lilqilrimesiwetesldlcllpygcistgdkigmieivkdattiakiqqstvgntgaf
kdevlnhwlkekspteekfqaaverfvyscagycvatfvlgigdrhndnimitetgnlfh
idfghkervpfvltpdflfvmgtsgkktsphfqkfqdicvkaylalrhhtnlliilfsmm
lmtgmpqltskedieyirdaltvgkneedakkyfldqievcrdkgwtvqfnwfl