PDB entry 4dch

View 4dch on RCSB PDB site
Description: Insights into Glucokinase Activation Mechanism: Observation of Multiple Distinct Protein Conformations
Class: transferase
Keywords: GK Beta Cell, small molecule, open conformation, Kinase, Transferase
Deposited on 2012-01-17, released 2012-02-08
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-11-15, with a file datestamp of 2017-11-10.
Experiment type: XRAY
Resolution: 1.79 Å
R-factor: N/A
AEROSPACI score: 0.37 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Glucokinase
    Species: Homo sapiens [TaxId:9606]
    Gene: GCK
    Database cross-references and differences (RAF-indexed):
    • Uniprot P35557 (Start-464)
      • expression tag (465-468)
    Domains in SCOPe 2.07: d4dcha1, d4dcha2, d4dcha3
  • Heterogens: GLC, 4DC, IOD, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4dchA (A:)
mlddrarmeaakkekveqilaefqlqeedlkkvmrrmqkemdrglrletheeasvkmlpt
yvrstpegsevgdflsldlggtnfrvmlvkvgegeegqwsvktkhqmysipedamtgtae
mlfdyisecisdfldkhqmkhkklplgftfsfpvrhedidkgillnwtkgfkasgaegnn
vvgllrdaikrrgdfemdvvamvndtvatmiscyyedhqcevgmivgtgcnacymeemqn
velvegdegrmcvntewgafgdsgeldeflleydrlvdessanpgqqlyekliggkymge
lvrlvllrlvdenllfhgeaseqlrtrgafetrfvsqvesdtgdrkqiynilstlglrps
ttdcdivrracesvstraahmcsaglagvinrmresrsedvmritvgvdgsvyklhpsfk
erfhasvrrltpsceitfieseegsgrgaalvsavackkacmlgqlehhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >4dchA (A:)
eaakkekveqilaefqlqeedlkkvmrrmqkemdrglrletheeasvkmlptyvrstpeg
sevgdflsldlggtnfrvmlvkvgeggqwsvktkhqmysipedamtgtaemlfdyiseci
sdfldkhqmkhkklplgftfsfpnnvvgllrdaikrrgdfemdvvamvndtvatmiscyy
edhqcevgmivgtgcnacymeemqnvelvegdegrmcvntewgafgdsgeldeflleydr
lvdessanpgqqlyekliggkymgelvrlvllrlvdenllfhgeaseqlrtrgafetrfv
sqvesdtgdrkqiynilstlglrpsttdcdivrracesvstraahmcsaglagvinrmre
srsedvmritvgvdgsvyklhpsfkerfhasvrrltpsceitfieseegsgrgaalvsav
ackkacmlgqlehh