PDB entry 4dc0

View 4dc0 on RCSB PDB site
Description: Crystal Structure of F189W Actinorhodin Polyketide Ketoreductase with NADPH
Class: oxidoreductase
Keywords: Rossmann fold, short-chain dehydrogenase/reductase, ketoreductase, OXIDOREDUCTASE
Deposited on 2012-01-16, released 2013-01-16
The last revision prior to the SCOPe 2.02 freeze date was dated 2013-01-16, with a file datestamp of 2013-01-11.
Experiment type: XRAY
Resolution: 2.81 Å
R-factor: 0.191
AEROSPACI score: 0.28 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: ketoacyl reductase
    Species: Streptomyces coelicolor [TaxId:1902]
    Gene: actIII, SCBAC28G1.12c, SCO5086
    Database cross-references and differences (RAF-indexed):
    • Uniprot P16544 (Start-280)
      • engineered mutation (208)
  • Chain 'B':
    Compound: ketoacyl reductase
    Species: Streptomyces coelicolor [TaxId:1902]
    Gene: actIII, SCBAC28G1.12c, SCO5086
    Database cross-references and differences (RAF-indexed):
    • Uniprot P16544 (20-280)
      • engineered mutation (208)
    Domains in SCOPe 2.02: d4dc0b_
  • Heterogens: NDP, HOH

PDB Chain Sequences:

  • Chain 'A':
    No sequence available.

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4dc0B (B:)
mgsshhhhhhssglvprgshmatqdsevalvtgatsgigleiarrlgkeglrvfvcarge
eglrttlkelreagveadgrtcdvrsvpeiealvaavverygpvdvlvnnagrpgggata
eladelwldvvetnltgvfrvtkqvlkaggmlergtgrivniastggkqgvvhaapysas
khgvvgftkalglelartgitvnavcpgwvetpmaasvrehysdiwevsteeafdritar
vpigryvqpsevaemvayligpgaaavtaqalnvcgglgny

    Sequence, based on observed residues (ATOM records): (download) 
    >4dc0B (B:)
matqdsevalvtgatsgigleiarrlgkeglrvfvcargeeglrttlkelreagveadgr
tcdvrsvpeiealvaavverygpvdvlvnnagrpgggataeladelwldvvetnltgvfr
vtkqvlkaggmlergtgrivniastggkqgvvhaapysaskhgvvgftkalglelartgi
tvnavcpgwvetpmaasvrehysdiwevsteeafdritarvpigryvqpsevaemvayli
gpgaaavtaqalnvcgglgny