PDB entry 4cxa

View 4cxa on RCSB PDB site
Description: Crystal structure of the human CDK12-cyclin K complex bound to AMPPNP
Class: transferase
Keywords: transferase, kinase
Deposited on 2014-04-04, released 2014-05-21
The last revision prior to the SCOPe 2.05 freeze date was dated 2014-05-21, with a file datestamp of 2014-05-16.
Experiment type: XRAY
Resolution: 3.15 Å
R-factor: 0.2239
AEROSPACI score: 0.15 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: cyclin-dependent kinase 12
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d4cxaa_
  • Chain 'B':
    Compound: cyclin-k
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d4cxab1, d4cxab2
  • Chain 'C':
    Compound: cyclin-dependent kinase 12
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d4cxac_
  • Chain 'D':
    Compound: cyclin-k
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d4cxad1, d4cxad2
  • Heterogens: ANP

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4cxaA (A:)
smtesdwgkrcvdkfdiigiigegtygqvykakdkdtgelvalkkvrldnekegfpitai
reikilrqlihrsvvnmkeivtdkqdaldfkkdkgafylvfeymdhdlmgllesglvhfs
edhiksfmkqlmegleychkknflhrdikcsnillnnsgqikladfglarlynseesrpy
tnkvitlwyrppelllgeerytpaidvwscgcilgelftkkpifqanlelaqlelisrlc
gspcpavwpdviklpyfntmkpkkqyrrrlreefsfipsaaldlldhmltldpskrctae
qtlqsdflkdvelskmappdlphwqdchelwskkrrrqrq

    Sequence, based on observed residues (ATOM records): (download) 
    >4cxaA (A:)
dwgkrcvdkfdiigiigegtygqvykakdkdtgelvalkkvrldnekegfpitaireiki
lrqlihrsvvnmkeivtdkqldfkkdkgafylvfeymdhdlmgllesglvhfsedhiksf
mkqlmegleychkknflhrdikcsnillnnsgqikladfglarlynseerpytnkvitlw
yrppelllgeerytpaidvwscgcilgelftkkpifqanlelaqlelisrlcgspcpavw
pdviklpyfntmkpkkqyrrrlreefsfipsaaldlldhmltldpskrctaeqtlqsdfl
kdvelskmappdlphwqdchelwskkrrrq

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4cxaB (B:)
smsvtsanldhtkpcwywdkkdlahtpsqlegldpatearyrregarfifdvgtrlglhy
dtlatgiiyfhrfymfhsfkqfpryvtgacclflagkveetpkkckdiiktarsllndvq
fgqfgddpkeevmvlerillqtikfdlqvehpyqfllkyakqlkgdknkiqklvqmawtf
vndslcttlslqwepeiiavavmylagrlckfeiqewtskpmyrrwweqfvqdvpvdvle
dichqildlysqgkqqmph

    Sequence, based on observed residues (ATOM records): (download) 
    >4cxaB (B:)
tkpcwywdkkdlahtpsqlegldpatearyrregarfifdvgtrlglhydtlatgiiyfh
rfymfhsfkqfpryvtgacclflagkveetpkkckdiiktarsllndvqfgqfgddpkee
vmvlerillqtikfdlqvehpyqfllkyakqlkgdknkiqklvqmawtfvndslcttlsl
qwepeiiavavmylagrlckfeiqewtskpmyrrwweqfvqdvpvdvledichqildlys
qgkqqm

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >4cxaC (C:)
smtesdwgkrcvdkfdiigiigegtygqvykakdkdtgelvalkkvrldnekegfpitai
reikilrqlihrsvvnmkeivtdkqdaldfkkdkgafylvfeymdhdlmgllesglvhfs
edhiksfmkqlmegleychkknflhrdikcsnillnnsgqikladfglarlynseesrpy
tnkvitlwyrppelllgeerytpaidvwscgcilgelftkkpifqanlelaqlelisrlc
gspcpavwpdviklpyfntmkpkkqyrrrlreefsfipsaaldlldhmltldpskrctae
qtlqsdflkdvelskmappdlphwqdchelwskkrrrqrq

    Sequence, based on observed residues (ATOM records): (download) 
    >4cxaC (C:)
dwgkrcvdkfdiigiigegtygqvykakdkdtgelvalkkvrldnekegfpitaireiki
lrqlihrsvvnmkeivtdkqdaldfkkdkgafylvfeymdhdlmgllesglvhfsedhik
sfmkqlmegleychkknflhrdikcsnillnnsgqikladfglarlynseesrpytnkvi
tlwyrppelllgeerytpaidvwscgcilgelftkkpifqanlelaqlelisrlcgspcp
avwpdviklpyfntmkpkkqyrrrlreefsfipsaaldlldhmltldpskrctaeqtlqs
dflkdvelskmappdlphwqdchelwskkrr

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >4cxaD (D:)
smsvtsanldhtkpcwywdkkdlahtpsqlegldpatearyrregarfifdvgtrlglhy
dtlatgiiyfhrfymfhsfkqfpryvtgacclflagkveetpkkckdiiktarsllndvq
fgqfgddpkeevmvlerillqtikfdlqvehpyqfllkyakqlkgdknkiqklvqmawtf
vndslcttlslqwepeiiavavmylagrlckfeiqewtskpmyrrwweqfvqdvpvdvle
dichqildlysqgkqqmph

    Sequence, based on observed residues (ATOM records): (download) 
    >4cxaD (D:)
pcwywdkkdlahtpsqlegldpatearyrregarfifdvgtrlglhydtlatgiiyfhrf
ymfhsfkqfpryvtgacclflagkveetpkkckdiiktarsllndvqfgqfgddpkeevm
vlerillqtikfdlqvehpyqfllkyakqlkgdknkiqklvqmawtfvndslcttlslqw
epeiiavavmylagrlckfeiqewtskpmyrrwweqfvqdvpvdvledichqildlysqg
k