PDB entry 4cwd

View 4cwd on RCSB PDB site
Description: crystal structure of human gamma-butyrobetaine,2-oxoglutarate in complex with 449, a novel substrate
Class: oxidoreductase
Keywords: oxidoreductase, 2-og and iron dependent dioxygenase, carnitine biosynthesis
Deposited on 2014-04-02, released 2014-09-17
The last revision prior to the SCOPe 2.06 freeze date was dated 2014-10-08, with a file datestamp of 2014-10-03.
Experiment type: XRAY
Resolution: 1.9 Å
R-factor: 0.1696
AEROSPACI score: 0.42 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Gamma-butyrobetaine dioxygenase
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot O75936 (1-End)
      • expression tag (0)
    Domains in SCOPe 2.06: d4cwda1, d4cwda2, d4cwda3
  • Heterogens: NI, ZN, 449, OGA, PEG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4cwdA (A:)
smactiqkaealdgahlmqilwydeeeslypavwlrdncpcsdcyldsakarkllveald
vnigikglifdrkkvyitwpdehysefqadwlkkrcfskqaraklqrelffpecqywgse
lqlptldfedvlrydehaykwlstlkkvgivrltgasdkpgevsklgkrmgflyltfygh
twqvqdkidannvayttgklsfhtdypalhhppgvqllhcikqtvtggdseivdgfnvcq
klkknnpqafqilsstfvdftdigvdycdfsvqskhkiielddkgqvvrinfnnatrdti
fdvpvervqpfyaalkefvdlmnskeskftfkmnpgdvitfdnwrllhgrrsyeagteis
rhlegayadwdvvmsrlrilrqrvengn

    Sequence, based on observed residues (ATOM records): (download) 
    >4cwdA (A:)
smactiqkaealdgahlmqilwydeeeslypavwlrdncpcsdcyldsakarkllveald
vnigikglifdrkkvyitwpdehysefqadwlkkrcfskqaraklqrelffpecqywgse
lqlptldfedvlrydehaykwlstlkkvgivrltgasdkpgevsklgkrmgflyltfygh
twqvqdkidannvayttgklsfhtdypalhhppgvqllhcikqtvtggdseivdgfnvcq
klkknnpqafqilsstfvdftdigvdycdfsvqskhkiielddkgqvvrinfnnatrdti
fdvpvervqpfyaalkefvdlmnskeskftfkmnpgdvitfdnwrllhgrrsyeagteis
rhlegayadwdvvmsrlrilrqrve