PDB entry 4cqe

View 4cqe on RCSB PDB site
Description: B-Raf Kinase V600E mutant in complex with a diarylthiazole B-Raf Inhibitor
Class: transferase
Keywords: transferase, inhibitor complex
Deposited on 2014-02-14, released 2014-12-10
The last revision prior to the SCOPe 2.04 freeze date was dated 2014-12-10, with a file datestamp of 2014-12-05.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: 0.21006
AEROSPACI score: 0.28 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: slc45a3-braf fusion protein
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot D7PBN4
      • engineered mutation (97-98)
      • engineered mutation (105)
      • engineered mutation (116)
      • engineered mutation (142)
      • engineered mutation (221)
      • engineered mutation (227)
      • engineered mutation (242)
      • engineered mutation (260)
      • engineered mutation (263)
      • engineered mutation (267)
      • engineered mutation (270)
      • engineered mutation (274)
    Domains in SCOPe 2.04: d4cqea_
  • Chain 'B':
    Compound: slc45a3-braf fusion protein
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot D7PBN4 (2-End)
      • engineered mutation (97-98)
      • engineered mutation (105)
      • engineered mutation (116)
      • engineered mutation (142)
      • engineered mutation (221)
      • engineered mutation (227)
      • engineered mutation (242)
      • engineered mutation (260)
      • engineered mutation (263)
      • engineered mutation (267)
      • engineered mutation (270)
      • engineered mutation (274)
    Domains in SCOPe 2.04: d4cqeb_
  • Heterogens: CQE, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4cqeA (A:)
gpddweipdgqitvgqrigsgsfgtvykgkwhgdvavkmlnvtaptpqqlqafknevgvl
rktrhvnillfmgystkpqlaivtqwcegsslyhhlhasetkfemkklidiarqtargmd
ylhaksiihrdlksnniflhedntvkigdfglateksrwsgshqfeqlsgsilwmapevi
rmqdsnpysfqsdvyafgivlyelmtgqlpysninnrdqiiemvgrgslspdlskvrsnc
pkrmkrlmaeclkkkrderpsfprilaeieelarelsg

    Sequence, based on observed residues (ATOM records): (download) 
    >4cqeA (A:)
dweipdgqitvgqrigsggtvykgkwhgdvavkmlnvtaptpqqlqafknevgvlrktrh
vnillfmgystkpqlaivtqwcegsslyhhlhasetkfemkklidiarqtargmdylhak
siihrdlksnniflhedntvkigdfggsilwmapevirmqnpysfqsdvyafgivlyelm
tgqlpysninnrdqiiemvgrgslspdlskvrsncpkrmkrlmaeclkkkrderpsfpri
laeieelare

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4cqeB (B:)
gpddweipdgqitvgqrigsgsfgtvykgkwhgdvavkmlnvtaptpqqlqafknevgvl
rktrhvnillfmgystkpqlaivtqwcegsslyhhlhasetkfemkklidiarqtargmd
ylhaksiihrdlksnniflhedntvkigdfglateksrwsgshqfeqlsgsilwmapevi
rmqdsnpysfqsdvyafgivlyelmtgqlpysninnrdqiiemvgrgslspdlskvrsnc
pkrmkrlmaeclkkkrderpsfprilaeieelarelsg

    Sequence, based on observed residues (ATOM records): (download) 
    >4cqeB (B:)
ddweipdgqitvgqrigsgtvykgkwhgdvavkmlnvtaptpqqlqafknevgvlrktrh
vnillfmgystkpqlaivtqwcegsslyhhlhasetkfemkklidiarqtargmdylhak
siihrdlksnniflhedntvkigdfggsilwmapevirnpysfqsdvyafgivlyelmtg
qlpysninnrdqiiemvgrgslspdlskvrsncpkrmkrlmaeclkkkrderpsfprila
eieelare