PDB entry 4ci9

View 4ci9 on RCSB PDB site
Description: Crystal structure of cathepsin A, apo-structure
Class: hydrolase
Keywords: hydrolase, drug discovery, serine carboxypeptidase, cardiovascular drug, heart failure, endothelin, tetrahedral intermediate, covalent inhibitor
Deposited on 2013-12-06, released 2014-02-26
The last revision prior to the SCOPe 2.07 freeze date was dated 2014-04-02, with a file datestamp of 2014-03-28.
Experiment type: XRAY
Resolution: 1.58 Å
R-factor: 0.1662
AEROSPACI score: 0.53 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: lysosomal protective protein
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P10619 (2-453)
      • expression tag (0-1)
      • expression tag (454)
    Domains in SCOPe 2.07: d4ci9a1, d4ci9a2, d4ci9a3
  • Heterogens: DMS, ACT, GOL, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4ci9A (A:)
srapdqdeiqrlpglakqpsfrqysgylkgsgskhlhywfvesqkdpenspvvlwlnggp
gcssldglltehgpflvqpdgvtleynpyswnlianvlylespagvgfsysddkfyatnd
tevaqsnfealqdffrlfpeyknnklfltgesyagiyiptlavlvmqdpsmnlqglavgn
glssyeqndnslvyfayyhgllgnrlwsslqthccsqnkcnfydnkdlecvtnlqevari
vgnsglniynlyapcaggvpshfryekdtvvvqdlgniftrlplkrmwhqallrsgdkvr
mdppctnttaastylnnpyvrkalnipeqlpqwdmcnflvnlqyrrlyrsmnsqylklls
sqkyqillyngdvdmacnfmgdewfvdslnqkmevqrrpwlvkygdsgeqiagfvkefsh
iafltikgaghmvptdkplaaftmfsrflnkqpye

    Sequence, based on observed residues (ATOM records): (download) 
    >4ci9A (A:)
srapdqdeiqrlpglakqpsfrqysgylkgsgskhlhywfvesqkdpenspvvlwlnggp
gcssldglltehgpflvqpdgvtleynpyswnlianvlylespagvgfsysddkfyatnd
tevaqsnfealqdffrlfpeyknnklfltgesyagiyiptlavlvmqdpsmnlqglavgn
glssyeqndnslvyfayyhgllgnrlwsslqthccsqnkcnfydnkdlecvtnlqevari
vgnsglniynlyapcaggvpsdppctnttaastylnnpyvrkalnipeqlpqwdmcnflv
nlqyrrlyrsmnsqylkllssqkyqillyngdvdmacnfmgdewfvdslnqkmevqrrpw
lvkygdsgeqiagfvkefshiafltikgaghmvptdkplaaftmfsrflnkqpye