PDB entry 4c71

View 4c71 on RCSB PDB site
Description: Crystal structure of M. tuberculosis C171Q KasA in complex with TLM18
Class: transferase
Keywords: transferase, beto-ketoacyl-acp synthase, kas enzyme, condensing enzyme, type 2 fatty acid biosynthesis, mycolic acid synthesis, thiolactomycin
Deposited on 2013-09-19, released 2013-10-09
The last revision prior to the SCOPe 2.06 freeze date was dated 2013-12-11, with a file datestamp of 2013-12-06.
Experiment type: XRAY
Resolution: 1.8 Å
R-factor: 0.14073
AEROSPACI score: 0.48 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: 3-oxoacyl-[acyl-carrier-protein] synthase 1
    Species: MYCOBACTERIUM TUBERCULOSIS H37RV [TaxId:83332]
    Database cross-references and differences (RAF-indexed):
    • Uniprot I6Y8T4 (Start-438)
      • engineered mutation (193)
    Domains in SCOPe 2.06: d4c71a1, d4c71a2
  • Chain 'B':
    Compound: 3-oxoacyl-[acyl-carrier-protein] synthase 1
    Species: MYCOBACTERIUM TUBERCULOSIS H37RV [TaxId:83332]
    Database cross-references and differences (RAF-indexed):
    • Uniprot I6Y8T4 (Start-438)
      • engineered mutation (193)
    Domains in SCOPe 2.06: d4c71b1, d4c71b2
  • Heterogens: EDO, K, FMT, 7RD, M7U, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4c71A (A:)
mgsshhhhhhssglvprgshmasmsqpstanggfpsvvvtavtattsispdiestwkgll
agesgihaledefvtkwdlavkigghlkdpvdshmgrldmrrmsyvqrmgkllggqlwes
agspevdpdrfavvvgtglggaerivesydlmnaggprkvsplavqmimpngaaaviglq
lgaragvmtpvsaqssgseaiahawrqivmgdadvavcggvegpiealpiaafsmmrams
trndeperasrpfdkdrdgfvfgeagalmlieteehakargakplarllgagitsdafhm
vapaadgvragramtrslelaglspadidhvnahgtatpigdaaeanairvagcdqaavy
apksalghsigavgalesvltvltlrdgvipptlnyetpdpeidldvvageprygdyrya
vnnsfgfgghnvalafgry

    Sequence, based on observed residues (ATOM records): (download) 
    >4c71A (A:)
sqpstanggfpsvvvtavtattsispdiestwkgllagesgihaledefvtkwdlavkig
ghlkdpvdshmgrldmrrmsyvqrmgkllggqlwesagspevdpdrfavvvgtglggaer
ivesydlmnaggprkvsplavqmimpngaaaviglqlgaragvmtpvsaqssgseaiaha
wrqivmgdadvavcggvegpiealpiaafsmmramstrndeperasrpfdkdrdgfvfge
agalmlieteehakargakplarllgagitsdafhmvapaadgvragramtrslelagls
padidhvnahgtatpigdaaeanairvagcdqaavyapksalghsigavgalesvltvlt
lrdgvipptlnyetpdpeidldvvageprygdyryavnnsfgfgghnvalafgry

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4c71B (B:)
mgsshhhhhhssglvprgshmasmsqpstanggfpsvvvtavtattsispdiestwkgll
agesgihaledefvtkwdlavkigghlkdpvdshmgrldmrrmsyvqrmgkllggqlwes
agspevdpdrfavvvgtglggaerivesydlmnaggprkvsplavqmimpngaaaviglq
lgaragvmtpvsaqssgseaiahawrqivmgdadvavcggvegpiealpiaafsmmrams
trndeperasrpfdkdrdgfvfgeagalmlieteehakargakplarllgagitsdafhm
vapaadgvragramtrslelaglspadidhvnahgtatpigdaaeanairvagcdqaavy
apksalghsigavgalesvltvltlrdgvipptlnyetpdpeidldvvageprygdyrya
vnnsfgfgghnvalafgry

    Sequence, based on observed residues (ATOM records): (download) 
    >4c71B (B:)
sqpstanggfpsvvvtavtattsispdiestwkgllagesgihaledefvtkwdlavkig
ghlkdpvdshmgrldmrrmsyvqrmgkllggqlwesagspevdpdrfavvvgtglggaer
ivesydlmnaggprkvsplavqmimpngaaaviglqlgaragvmtpvsaqssgseaiaha
wrqivmgdadvavcggvegpiealpiaafsmmramstrndeperasrpfdkdrdgfvfge
agalmlieteehakargakplarllgagitsdafhmvapaadgvragramtrslelagls
padidhvnahgtatpigdaaeanairvagcdqaavyapksalghsigavgalesvltvlt
lrdgvipptlnyetpdpeidldvvageprygdyryavnnsfgfgghnvalafgry