PDB entry 4bvw

View 4bvw on RCSB PDB site
Description: Identification of small molecule inhibitors selective for apo(a) kringles KIV-7, KIV-10 and KV.
Class: hydrolase
Keywords: hydrolase, cardiovascular disease, drug discovery, optical biosensors
Deposited on 2013-06-28, released 2014-07-16
The last revision prior to the SCOPe 2.04 freeze date was dated 2014-07-16, with a file datestamp of 2014-07-11.
Experiment type: XRAY
Resolution: 2 Å
R-factor: 0.19399
AEROSPACI score: 0.37 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: apolipoprotein(a)
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P08519 (19-97)
      • engineered mutation (93)
    Domains in SCOPe 2.04: d4bvwa_
  • Chain 'B':
    Compound: apolipoprotein(a)
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P08519 (19-97)
      • engineered mutation (93)
    Domains in SCOPe 2.04: d4bvwb_
  • Heterogens: CL, HKY, EDO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4bvwA (A:)
siaakeegvslekrsiarsdcyhgdgqsyrgsfsttvtgrtcqswssmtphwhqrtteyy
pnggltrnycrnpdaeirpwcytmdpsvrweycaltqc

    Sequence, based on observed residues (ATOM records): (download) 
    >4bvwA (A:)
dcyhgdgqsyrgsfsttvtgrtcqswssmtphwhqrtteyypnggltrnycrnpdaeirp
wcytmdpsvrweycaltqc

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4bvwB (B:)
siaakeegvslekrsiarsdcyhgdgqsyrgsfsttvtgrtcqswssmtphwhqrtteyy
pnggltrnycrnpdaeirpwcytmdpsvrweycaltqc

    Sequence, based on observed residues (ATOM records): (download) 
    >4bvwB (B:)
dcyhgdgqsyrgsfsttvtgrtcqswssmtphwhqrtteyypnggltrnycrnpdaeirp
wcytmdpsvrweycaltqc