PDB entry 4btt

View 4btt on RCSB PDB site
Description: factor Xa in complex with the dual thrombin-FXa inhibitor 31.
Class: hydrolase
Keywords: hydrolase, sar107375, factor xa inhibitor, thrombin inhibitor, chlorothiophene p1 fragment, s3 subsite, microsomes stability, oral antithrombotic, dual inhibitor, IV antithrombotic
Deposited on 2013-06-19, released 2013-12-18
The last revision prior to the SCOPe 2.06 freeze date was dated 2014-01-15, with a file datestamp of 2014-01-10.
Experiment type: XRAY
Resolution: 2.59 Å
R-factor: 0.201
AEROSPACI score: 0.24 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: coagulation factor x light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d4btta_
  • Chain 'B':
    Compound: coagulation factor x
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d4bttb_
  • Chain 'E':
    Compound: coagulation factor x light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d4btte_
  • Chain 'F':
    Compound: coagulation factor x
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d4bttf_
  • Heterogens: CA, VYR, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4bttA (A:)
ykdgdqcetspcqnqgkckdglgeytctclegfegkncelftrklcsldngdcdqfchee
qnsvvcscargytladngkaciptgpypcgkqtler

    Sequence, based on observed residues (ATOM records): (download) 
    >4bttA (A:)
rklcsldngdcdqfcheeqnsvvcscargytladngkaciptgpypcgkqt

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4bttB (B:)
ivggqeckdgecpwqallineenegfcggtilsefyiltaahclyqakrfkvrvgdrnte
qeeggeavhevevvikhnrftketydfdiavlrlktpitfrmnvapaclperdwaestlm
tqktgivsgfgrthekgrqstrlkmlevpyvdrnscklsssfiitqnmfcagydtkqeda
cqgdsggphvtrfkdtyfvtgivswgegcarkgkygiytkvtaflkwidrsmktrglpka
kshapevitssplk

    Sequence, based on observed residues (ATOM records): (download) 
    >4bttB (B:)
ivggqeckdgecpwqallineenegfcggtilsefyiltaahclyqakrfkvrvgdrnte
qeeggeavhevevvikhnrftketydfdiavlrlktpitfrmnvapaclperdwaestlm
tqktgivsgfgrthekgrqstrlkmlevpyvdrnscklsssfiitqnmfcagydtkqeda
cqgdsggphvtrfkdtyfvtgivswgegcarkgkygiytkvtaflkwidrsmktr

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >4bttE (E:)
ykdgdqcetspcqnqgkckdglgeytctclegfegkncelftrklcsldngdcdqfchee
qnsvvcscargytladngkaciptgpypcgkqtler

    Sequence, based on observed residues (ATOM records): (download) 
    >4bttE (E:)
klcsldngdcdqfcheeqnsvvcscargytladngkaciptgpypcgkqtler

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >4bttF (F:)
ivggqeckdgecpwqallineenegfcggtilsefyiltaahclyqakrfkvrvgdrnte
qeeggeavhevevvikhnrftketydfdiavlrlktpitfrmnvapaclperdwaestlm
tqktgivsgfgrthekgrqstrlkmlevpyvdrnscklsssfiitqnmfcagydtkqeda
cqgdsggphvtrfkdtyfvtgivswgegcarkgkygiytkvtaflkwidrsmktrglpka
kshapevitssplk

    Sequence, based on observed residues (ATOM records): (download) 
    >4bttF (F:)
ivggqeckdgecpwqallineenegfcggtilsefyiltaahclyqakrfkvrvgdrnte
qeeggeavhevevvikhnrftketydfdiavlrlktpitfrmnvapaclperdwaestlm
tqktgivsgfgrthekgrqstrlkmlevpyvdrnscklsssfiitqnmfcagydtkqeda
cqgdsggphvtrfkdtyfvtgivswgegcarkgkygiytkvtaflkwidrsmktr