SCOPe 2.04: Structural Classification of Proteins

PDB entry 4a6a

View 4a6a on RCSB PDB site
Description: A115V variant of dCTP deaminase-dUTPase from Mycobacterium tuberculosis in complex with dTTP
Class: hydrolase
Keywords: hydrolase, deoxy-ribonucleotide metabolism, dttp inhibition
Deposited on 2011-11-01, released 2012-10-10
The last revision prior to the SCOPe 2.04 freeze date was dated 2012-12-26, with a file datestamp of 2012-12-21.
Experiment type: XRAY
Resolution: 2.9 Å
R-factor: 0.25478
AEROSPACI score: 0.21 (click here for full SPACI score report)

Chains and heterogens:

Chain 'A':
Compound: deoxycytidine triphosphate deaminase
Species: Mycobacterium tuberculosis [TaxId:83332]
Database cross-references and differences (RAF-indexed):
- Uniprot O07247 (0-End)
  - engineered mutation (114)
Domains in SCOPe 2.04: d4a6aa_
Chain 'B':
Compound: deoxycytidine triphosphate deaminase
Species: Mycobacterium tuberculosis [TaxId:83332]
Database cross-references and differences (RAF-indexed):
- Uniprot O07247 (0-End)
  - engineered mutation (114)
Domains in SCOPe 2.04: d4a6ab_
Chain 'C':
Compound: deoxycytidine triphosphate deaminase
Species: Mycobacterium tuberculosis [TaxId:83332]
Database cross-references and differences (RAF-indexed):
- Uniprot O07247 (0-End)
  - engineered mutation (114)
Domains in SCOPe 2.04: d4a6ac_
Chain 'D':
Compound: deoxycytidine triphosphate deaminase
Species: Mycobacterium tuberculosis [TaxId:83332]
Database cross-references and differences (RAF-indexed):
- Uniprot O07247 (0-End)
  - engineered mutation (114)
Domains in SCOPe 2.04: d4a6ad_
Chain 'E':
Compound: deoxycytidine triphosphate deaminase
Species: Mycobacterium tuberculosis [TaxId:83332]
Database cross-references and differences (RAF-indexed):
- Uniprot O07247 (0-End)
  - engineered mutation (114)
Domains in SCOPe 2.04: d4a6ae_
Chain 'F':
Compound: deoxycytidine triphosphate deaminase
Species: Mycobacterium tuberculosis [TaxId:83332]
Database cross-references and differences (RAF-indexed):
- Uniprot O07247 (0-End)
  - engineered mutation (114)
Domains in SCOPe 2.04: d4a6af_
Chain 'G':
Compound: deoxycytidine triphosphate deaminase
Species: Mycobacterium tuberculosis [TaxId:83332]
Database cross-references and differences (RAF-indexed):
- Uniprot O07247 (0-End)
  - engineered mutation (114)
Domains in SCOPe 2.04: d4a6ag_
Chain 'H':
Compound: deoxycytidine triphosphate deaminase
Species: Mycobacterium tuberculosis [TaxId:83332]
Database cross-references and differences (RAF-indexed):
- Uniprot O07247 (0-End)
  - engineered mutation (114)
Domains in SCOPe 2.04: d4a6ah_
Chain 'I':
Compound: deoxycytidine triphosphate deaminase
Species: Mycobacterium tuberculosis [TaxId:83332]
Database cross-references and differences (RAF-indexed):
- Uniprot O07247 (0-End)
  - engineered mutation (114)
Domains in SCOPe 2.04: d4a6ai_
Chain 'J':
Compound: deoxycytidine triphosphate deaminase
Species: Mycobacterium tuberculosis [TaxId:83332]
Database cross-references and differences (RAF-indexed):
- Uniprot O07247 (0-End)
  - engineered mutation (114)
Domains in SCOPe 2.04: d4a6aj_
Chain 'K':
Compound: deoxycytidine triphosphate deaminase
Species: Mycobacterium tuberculosis [TaxId:83332]
Database cross-references and differences (RAF-indexed):
- Uniprot O07247 (0-End)
  - engineered mutation (114)
Domains in SCOPe 2.04: d4a6ak_
Chain 'L':
Compound: deoxycytidine triphosphate deaminase
Species: Mycobacterium tuberculosis [TaxId:83332]
Database cross-references and differences (RAF-indexed):
- Uniprot O07247 (0-End)
  - engineered mutation (114)
Domains in SCOPe 2.04: d4a6al_
Heterogens: TTP, MG, HOH

PDB Chain Sequences:

Chain 'A':
Sequence, based on SEQRES records: (download)

>4a6aA (A:)
mllsdrdlraeissgrlgidpfddtlvqpssidvrldclfrvfnntrythidpakqqdel
tslvqpvdgepfvlhpgefvlgstlelftlpdnlagrlegksslgrlgllthstvgfidp
gfsghitlelsnvanlpitlwpgmkigqlcmlrltspsehpygssragskyqgqrgptps
rsyqnfirst