PDB entry 3wiy

View 3wiy on RCSB PDB site
Description: Crystal structure of Mcl-1 in complex with compound 10
Class: apoptosis
Keywords: regulation, apoptosis
Deposited on 2013-09-26, released 2013-11-27
The last revision prior to the SCOPe 2.07 freeze date was dated 2014-03-12, with a file datestamp of 2014-03-07.
Experiment type: XRAY
Resolution: 2.15 Å
R-factor: 0.214
AEROSPACI score: 0.31 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Induced myeloid leukemia cell differentiation protein Mcl-1
    Species: Homo sapiens [TaxId:9606]
    Gene: MCL1, BCL2L3
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d3wiya_
  • Chain 'B':
    Compound: Induced myeloid leukemia cell differentiation protein Mcl-1
    Species: Homo sapiens [TaxId:9606]
    Gene: MCL1, BCL2L3
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d3wiyb_
  • Chain 'C':
    Compound: Induced myeloid leukemia cell differentiation protein Mcl-1
    Species: Homo sapiens [TaxId:9606]
    Gene: MCL1, BCL2L3
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d3wiyc_
  • Chain 'D':
    Compound: Induced myeloid leukemia cell differentiation protein Mcl-1
    Species: Homo sapiens [TaxId:9606]
    Gene: MCL1, BCL2L3
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d3wiyd_
  • Chain 'E':
    Compound: Induced myeloid leukemia cell differentiation protein Mcl-1
    Species: Homo sapiens [TaxId:9606]
    Gene: MCL1, BCL2L3
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d3wiye_
  • Chain 'F':
    Compound: Induced myeloid leukemia cell differentiation protein Mcl-1
    Species: Homo sapiens [TaxId:9606]
    Gene: MCL1, BCL2L3
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d3wiyf_
  • Heterogens: LC6, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3wiyA (A:)
gplgsdelyrqsleiisrylreqatgakdtkpmgrsgatsrkaletlrrvgdgvqrnhet
afqgmlrkldikneddvkslsrvmihvfsdgvtnwgrivtlisfgafvakhlktinqesc
ieplaesitdvlvrtkrdwlvkqrgwdgfveffhvedlegg

    Sequence, based on observed residues (ATOM records): (download) 
    >3wiyA (A:)
delyrqsleiisrylreqatgakdtkpmgrsgatsrkaletlrrvgdgvqrnhetafqgm
lrkldikneddvkslsrvmihvfsdgvtnwgrivtlisfgafvakhlktinqesciepla
esitdvlvrtkrdwlvkqrgwdgfveffhved

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3wiyB (B:)
gplgsdelyrqsleiisrylreqatgakdtkpmgrsgatsrkaletlrrvgdgvqrnhet
afqgmlrkldikneddvkslsrvmihvfsdgvtnwgrivtlisfgafvakhlktinqesc
ieplaesitdvlvrtkrdwlvkqrgwdgfveffhvedlegg

    Sequence, based on observed residues (ATOM records): (download) 
    >3wiyB (B:)
delyrqsleiisrylreqatgakdtkpmgrsgatsrkaletlrrvgdgvqrnhetafqgm
lrkldikneddvkslsrvmihvfsdgvtnwgrivtlisfgafvakhlktinqesciepla
esitdvlvrtkrdwlvkqrgwdgfveffhve

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >3wiyC (C:)
gplgsdelyrqsleiisrylreqatgakdtkpmgrsgatsrkaletlrrvgdgvqrnhet
afqgmlrkldikneddvkslsrvmihvfsdgvtnwgrivtlisfgafvakhlktinqesc
ieplaesitdvlvrtkrdwlvkqrgwdgfveffhvedlegg

    Sequence, based on observed residues (ATOM records): (download) 
    >3wiyC (C:)
delyrqsleiisrylreqatgakdtkpmgrsgatsrkaletlrrvgdgvqrnhetafqgm
lrkldikneddvkslsrvmihvfsdgvtnwgrivtlisfgafvakhlktinqesciepla
esitdvlvrtkrdwlvkqrgwdgfveffhv

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >3wiyD (D:)
gplgsdelyrqsleiisrylreqatgakdtkpmgrsgatsrkaletlrrvgdgvqrnhet
afqgmlrkldikneddvkslsrvmihvfsdgvtnwgrivtlisfgafvakhlktinqesc
ieplaesitdvlvrtkrdwlvkqrgwdgfveffhvedlegg

    Sequence, based on observed residues (ATOM records): (download) 
    >3wiyD (D:)
delyrqsleiisrylreqatgakdtkpmgrsgatsrkaletlrrvgdgvqrnhetafqgm
lrkldikneddvkslsrvmihvfsdgvtnwgrivtlisfgafvakhlktinqesciepla
esitdvlvrtkrdwlvkqrgwdgfveffhv

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >3wiyE (E:)
gplgsdelyrqsleiisrylreqatgakdtkpmgrsgatsrkaletlrrvgdgvqrnhet
afqgmlrkldikneddvkslsrvmihvfsdgvtnwgrivtlisfgafvakhlktinqesc
ieplaesitdvlvrtkrdwlvkqrgwdgfveffhvedlegg

    Sequence, based on observed residues (ATOM records): (download) 
    >3wiyE (E:)
delyrqsleiisrylreqatgakdtkpmgrsgatsrkaletlrrvgdgvqrnhetafqgm
lrkldikneddvkslsrvmihvfsdgvtnwgrivtlisfgafvakhlktinqesciepla
esitdvlvrtkrdwlvkqrgwdgfveffhved

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >3wiyF (F:)
gplgsdelyrqsleiisrylreqatgakdtkpmgrsgatsrkaletlrrvgdgvqrnhet
afqgmlrkldikneddvkslsrvmihvfsdgvtnwgrivtlisfgafvakhlktinqesc
ieplaesitdvlvrtkrdwlvkqrgwdgfveffhvedlegg

    Sequence, based on observed residues (ATOM records): (download) 
    >3wiyF (F:)
delyrqsleiisrylreqatgakdtkpmgrsgatsrkaletlrrvgdgvqrnhetafqgm
lrkldikneddvkslsrvmihvfsdgvtnwgrivtlisfgafvakhlktinqesciepla
esitdvlvrtkrdwlvkqrgwdgfveffhv