PDB entry 3vqu

View 3vqu on RCSB PDB site
Description: CRYSTAL STRUCTURE OF HUMAN MPS1 CATALYTIC DOMAIN IN COMPLEX WITH 4-[(4-amino-5-cyano-6-ethoxypyridin-2- yl)amino]benzamide
Class: transferase/transferase inhibitor
Keywords: KINASE, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on 2012-03-30, released 2012-06-27
The last revision prior to the SCOPe 2.04 freeze date was dated 2012-06-27, with a file datestamp of 2012-06-22.
Experiment type: XRAY
Resolution: 2.4 Å
R-factor: 0.251
AEROSPACI score: 0.28 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Dual specificity protein kinase TTK
    Species: Homo sapiens [TaxId:9606]
    Gene: TTK, MPS1, MPS1L1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d3vqua_
  • Heterogens: IOD, O22, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3vquA (A:)
ecisvkgriysilkqigsggsskvfqvlnekkqiyaikyvnleeadnqtldsyrneiayl
nklqqhsdkiirlydyeitdqyiymvmecgnidlnswlkkkksidpwerksywknmleav
htihqhgivhsdlkpanflivdgmlklidfgianqmqpdttsvvkdsqvgtvnymppeai
kdmsssrengkskskispksdvwslgcilyymtygktpfqqiinqisklhaiidpnheie
fpdipekdlqdvlkcclkrdpkqrisipellahpyvqiqthpvnqmakgtteemkyvlgq
lvglnlvprgsaaghhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >3vquA (A:)
ecisvkgriysilkqigsggsskvfqvlnekkqiyaikyvnleadnqtldsyrneiayln
klqqhsdkiirlydyeitdqyiymvmecgnidlnswlkkkksidpwerksywknmleavh
tihqhgivhsdlkpanflivdgmlklidfgianqmqpdgtvnymppeaikdmsispksdv
wslgcilyymtygktpfqqiinqisklhaiidpnheiefpdipekdlqdvlkcclkrdpk
qrisipellahpyvqiqt