PDB entry 3vjl

View 3vjl on RCSB PDB site
Description: Crystal structure of human depiptidyl peptidase IV (DPP-4) in complex with a prolylthiazolidine inhibitor #2
Class: hydrolase/hydrolase inhibitor
Keywords: ALPHA/BETA, BETA-PROPELLER, AMINOPEPTIDASE, SERINE PROTEASE, SIGNAL-ANCHOR, TRANSMEMBRANE, DIABETES, GLYCOPROTEIN, CELL MEMBRANE, HYDROLASE-HYDROLASE INHIBITOR complex
Deposited on 2011-10-24, released 2012-10-24
The last revision prior to the SCOPe 2.06 freeze date was dated 2012-10-24, with a file datestamp of 2012-10-19.
Experiment type: XRAY
Resolution: 2.39 Å
R-factor: 0.186
AEROSPACI score: 0.36 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: dipeptidyl peptidase 4
    Species: Homo sapiens [TaxId:9606]
    Gene: DPP4, ADCP2, CD26
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d3vjla1, d3vjla2
  • Chain 'B':
    Compound: dipeptidyl peptidase 4
    Species: Homo sapiens [TaxId:9606]
    Gene: DPP4, ADCP2, CD26
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d3vjlb1, d3vjlb2
  • Heterogens: W94, NAG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3vjlA (A:)
ddatadsrktytltdylkntyrlklyslrwisdheylykqennilvfnaeygnssvflen
stfdefghsindysispdgqfilleynyvkqwrhsytasydiydlnkrqliteeripnnt
qwvtwspvghklayvwnndiyvkiepnlpsyritwtgkediiyngitdwvyeeevfsays
alwwspngtflayaqfndtevplieysfysdeslqypktvrvpypkagavnptvkffvvn
tdslssvtnatsiqitapasmligdhylcdvtwatqerislqwlrriqnysvmdicdyde
ssgrwnclvarqhiemsttgwvgrfrpsephftldgnsfykiisneegyrhicyfqidkk
dctfitkgtwevigiealtsdylyyisneykgmpggrnlykiqlsdytkvtclscelnpe
rcqyysvsfskeakyyqlrcsgpglplytlhssvndkglrvlednsaldkmlqnvqmpsk
kldfiilnetkfwyqmilpphfdkskkypllldvyagpcsqkadtvfrlnwatylasten
iivasfdgrgsgyqgdkimhainrrlgtfevedqieaarqfskmgfvdnkriaiwgwsyg
gyvtsmvlgsgsgvfkcgiavapvsrweyydsvyterymglptpednldhyrnstvmsra
enfkqveyllihgtaddnvhfqqsaqiskalvdvgvdfqamwytdedhgiasstahqhiy
thmshfikqcfslphhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >3vjlA (A:)
dsrktytltdylkntyrlklyslrwisdheylykqennilvfnaeygnssvflenstfde
fghsindysispdgqfilleynyvkqwrhsytasydiydlnkrqliteeripnntqwvtw
spvghklayvwnndiyvkiepnlpsyritwtgkediiyngitdwvyeeevfsaysalwws
pngtflayaqfndtevplieysfysdeslqypktvrvpypkagavnptvkffvvntdsls
svtnatsiqitapasmligdhylcdvtwatqerislqwlrriqnysvmdicdydessgrw
nclvarqhiemsttgwvgrfrpsephftldgnsfykiisneegyrhicyfqidkkdctfi
tkgtwevigiealtsdylyyisneykgmpggrnlykiqlsdytkvtclscelnpercqyy
svsfskeakyyqlrcsgpglplytlhssvndkglrvlednsaldkmlqnvqmpskkldfi
ilnetkfwyqmilpphfdkskkypllldvyagpcsqkadtvfrlnwatylasteniivas
fdgrgsgyqgdkimhainrrlgtfevedqieaarqfskmgfvdnkriaiwgwsyggyvts
mvlgsgsgvfkcgiavapvsrweyydsvyterymglptpednldhyrnstvmsraenfkq
veyllihgtaddnvhfqqsaqiskalvdvgvdfqamwytdedhgiasstahqhiythmsh
fikqcfslp

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3vjlB (B:)
ddatadsrktytltdylkntyrlklyslrwisdheylykqennilvfnaeygnssvflen
stfdefghsindysispdgqfilleynyvkqwrhsytasydiydlnkrqliteeripnnt
qwvtwspvghklayvwnndiyvkiepnlpsyritwtgkediiyngitdwvyeeevfsays
alwwspngtflayaqfndtevplieysfysdeslqypktvrvpypkagavnptvkffvvn
tdslssvtnatsiqitapasmligdhylcdvtwatqerislqwlrriqnysvmdicdyde
ssgrwnclvarqhiemsttgwvgrfrpsephftldgnsfykiisneegyrhicyfqidkk
dctfitkgtwevigiealtsdylyyisneykgmpggrnlykiqlsdytkvtclscelnpe
rcqyysvsfskeakyyqlrcsgpglplytlhssvndkglrvlednsaldkmlqnvqmpsk
kldfiilnetkfwyqmilpphfdkskkypllldvyagpcsqkadtvfrlnwatylasten
iivasfdgrgsgyqgdkimhainrrlgtfevedqieaarqfskmgfvdnkriaiwgwsyg
gyvtsmvlgsgsgvfkcgiavapvsrweyydsvyterymglptpednldhyrnstvmsra
enfkqveyllihgtaddnvhfqqsaqiskalvdvgvdfqamwytdedhgiasstahqhiy
thmshfikqcfslphhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >3vjlB (B:)
dsrktytltdylkntyrlklyslrwisdheylykqennilvfnaeygnssvflenstfde
fghsindysispdgqfilleynyvkqwrhsytasydiydlnkrqliteeripnntqwvtw
spvghklayvwnndiyvkiepnlpsyritwtgkediiyngitdwvyeeevfsaysalwws
pngtflayaqfndtevplieysfysdeslqypktvrvpypkagavnptvkffvvntdsls
svtnatsiqitapasmligdhylcdvtwatqerislqwlrriqnysvmdicdydessgrw
nclvarqhiemsttgwvgrfrpsephftldgnsfykiisneegyrhicyfqidkkdctfi
tkgtwevigiealtsdylyyisneykgmpggrnlykiqlsdytkvtclscelnpercqyy
svsfskeakyyqlrcsgpglplytlhssvndkglrvlednsaldkmlqnvqmpskkldfi
ilnetkfwyqmilpphfdkskkypllldvyagpcsqkadtvfrlnwatylasteniivas
fdgrgsgyqgdkimhainrrlgtfevedqieaarqfskmgfvdnkriaiwgwsyggyvts
mvlgsgsgvfkcgiavapvsrweyydsvyterymglptpednldhyrnstvmsraenfkq
veyllihgtaddnvhfqqsaqiskalvdvgvdfqamwytdedhgiasstahqhiythmsh
fikqcfslp