PDB entry 3v4y

View 3v4y on RCSB PDB site
Description: Crystal Structure of the first Nuclear PP1 holoenzyme
Class: hydrolase
Keywords: PP1, Ser/Thr phosphatase, NIPP1, IDP, HYDROLASE
Deposited on 2011-12-15, released 2012-10-31
The last revision prior to the SCOPe 2.08 freeze date was dated 2012-10-31, with a file datestamp of 2012-10-26.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: 0.156
AEROSPACI score: 0.46 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Serine/threonine-protein phosphatase PP1-alpha catalytic subunit
    Species: Homo sapiens [TaxId:9606]
    Gene: PPP1A, PPP1CA
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3v4ya_
  • Chain 'B':
    Compound: Nuclear inhibitor of protein phosphatase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: PPP1R8, ARD1, NIPP1
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: Serine/threonine-protein phosphatase PP1-alpha catalytic subunit
    Species: Homo sapiens [TaxId:9606]
    Gene: PPP1A, PPP1CA
    Database cross-references and differences (RAF-indexed):
    • Uniprot P62136 (5-End)
      • expression tag (4)
    Domains in SCOPe 2.08: d3v4yc1, d3v4yc2
  • Chain 'D':
    Compound: Nuclear inhibitor of protein phosphatase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: PPP1R8, ARD1, NIPP1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q12972 (3-End)
      • expression tag (1-2)
  • Chain 'E':
    Compound: Serine/threonine-protein phosphatase PP1-alpha catalytic subunit
    Species: Homo sapiens [TaxId:9606]
    Gene: PPP1A, PPP1CA
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3v4ye_
  • Chain 'F':
    Compound: Nuclear inhibitor of protein phosphatase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: PPP1R8, ARD1, NIPP1
    Database cross-references and differences (RAF-indexed):
  • Chain 'G':
    Compound: Serine/threonine-protein phosphatase PP1-alpha catalytic subunit
    Species: Homo sapiens [TaxId:9606]
    Gene: PPP1A, PPP1CA
    Database cross-references and differences (RAF-indexed):
    • Uniprot P62136 (5-End)
      • expression tag (0-4)
    Domains in SCOPe 2.08: d3v4yg1, d3v4yg2
  • Chain 'H':
    Compound: Nuclear inhibitor of protein phosphatase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: PPP1R8, ARD1, NIPP1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q12972 (3-End)
      • expression tag (1-2)
  • Heterogens: MN, GOL, 15P, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3v4yA (A:)
ghmgslnldsiigrllevqgsrpgknvqlteneirglclksreiflsqpilleleaplki
cgdihgqyydllrlfeyggfppesnylflgdyvdrgkqsleticlllaykikypenffll
rgnhecasinriygfydeckrryniklwktftdcfnclpiaaivdekifcchgglspdlq
smeqirrimrptdvpdqgllcdllwsdpdkdvqgwgendrgvsftfgaevvakflhkhdl
dlicrahqvvedgyeffakrqlvtlfsapnycgefdnagammsvdetlmcsfqilkpadk
nkgkyg

    Sequence, based on observed residues (ATOM records): (download) 
    >3v4yA (A:)
lnldsiigrllevqgsrpgknvqlteneirglclksreiflsqpilleleaplkicgdih
gqyydllrlfeyggfppesnylflgdyvdrgkqsleticlllaykikypenffllrgnhe
casinriygfydeckrryniklwktftdcfnclpiaaivdekifcchgglspdlqsmeqi
rrimrptdvpdqgllcdllwsdpdkdvqgwgendrgvsftfgaevvakflhkhdldlicr
ahqvvedgyeffakrqlvtlfsapnycgefdnagammsvdetlmcsfqilkpa

  • Chain 'B':
    No sequence available.

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >3v4yC (C:)
ghmgslnldsiigrllevqgsrpgknvqlteneirglclksreiflsqpilleleaplki
cgdihgqyydllrlfeyggfppesnylflgdyvdrgkqsleticlllaykikypenffll
rgnhecasinriygfydeckrryniklwktftdcfnclpiaaivdekifcchgglspdlq
smeqirrimrptdvpdqgllcdllwsdpdkdvqgwgendrgvsftfgaevvakflhkhdl
dlicrahqvvedgyeffakrqlvtlfsapnycgefdnagammsvdetlmcsfqilkpadk
nkgkyg

    Sequence, based on observed residues (ATOM records): (download) 
    >3v4yC (C:)
slnldsiigrllevqgsrpgknvqlteneirglclksreiflsqpilleleaplkicgdi
hgqyydllrlfeyggfppesnylflgdyvdrgkqsleticlllaykikypenffllrgnh
ecasinriygfydeckrryniklwktftdcfnclpiaaivdekifcchgglspdlqsmeq
irrimrptdvpdqgllcdllwsdpdkdvqgwgendrgvsftfgaevvakflhkhdldlic
rahqvvedgyeffakrqlvtlfsapnycgefdnagammsvdetlmcsfqilkpad

  • Chain 'D':
    No sequence available.

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >3v4yE (E:)
ghmgslnldsiigrllevqgsrpgknvqlteneirglclksreiflsqpilleleaplki
cgdihgqyydllrlfeyggfppesnylflgdyvdrgkqsleticlllaykikypenffll
rgnhecasinriygfydeckrryniklwktftdcfnclpiaaivdekifcchgglspdlq
smeqirrimrptdvpdqgllcdllwsdpdkdvqgwgendrgvsftfgaevvakflhkhdl
dlicrahqvvedgyeffakrqlvtlfsapnycgefdnagammsvdetlmcsfqilkpadk
nkgkyg

    Sequence, based on observed residues (ATOM records): (download) 
    >3v4yE (E:)
lnldsiigrllevqgsrpgknvqlteneirglclksreiflsqpilleleaplkicgdih
gqyydllrlfeyggfppesnylflgdyvdrgkqsleticlllaykikypenffllrgnhe
casinriygfydeckrryniklwktftdcfnclpiaaivdekifcchgglspdlqsmeqi
rrimrptdvpdqgllcdllwsdpdkdvqgwgendrgvsftfgaevvakflhkhdldlicr
ahqvvedgyeffakrqlvtlfsapnycgefdnagammsvdetlmcsfqilkpa

  • Chain 'F':
    No sequence available.

  • Chain 'G':
    Sequence, based on SEQRES records: (download) 
    >3v4yG (G:)
ghmgslnldsiigrllevqgsrpgknvqlteneirglclksreiflsqpilleleaplki
cgdihgqyydllrlfeyggfppesnylflgdyvdrgkqsleticlllaykikypenffll
rgnhecasinriygfydeckrryniklwktftdcfnclpiaaivdekifcchgglspdlq
smeqirrimrptdvpdqgllcdllwsdpdkdvqgwgendrgvsftfgaevvakflhkhdl
dlicrahqvvedgyeffakrqlvtlfsapnycgefdnagammsvdetlmcsfqilkpadk
nkgkyg

    Sequence, based on observed residues (ATOM records): (download) 
    >3v4yG (G:)
ghmgslnldsiigrllevqgsrpgknvqlteneirglclksreiflsqpilleleaplki
cgdihgqyydllrlfeyggfppesnylflgdyvdrgkqsleticlllaykikypenffll
rgnhecasinriygfydeckrryniklwktftdcfnclpiaaivdekifcchgglspdlq
smeqirrimrptdvpdqgllcdllwsdpdkdvqgwgendrgvsftfgaevvakflhkhdl
dlicrahqvvedgyeffakrqlvtlfsapnycgefdnagammsvdetlmcsfqilkp

  • Chain 'H':
    No sequence available.