PDB entry 3u7u

View 3u7u on RCSB PDB site
Description: Crystal structure of extracellular region of human epidermal growth factor receptor 4 in complex with neuregulin-1 beta
Class: transferase/transferase regulator
Keywords: signaling protein, TRANSFERASE-TRANSFERASE REGULATOR COMPLEX, Glycosylation
Deposited on 2011-10-14, released 2012-08-29
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-07-29, with a file datestamp of 2020-07-04.
Experiment type: XRAY
Resolution: 3.03 Å
R-factor: N/A
AEROSPACI score: 0.19 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Receptor tyrosine-protein kinase erbB-4
    Species: Homo sapiens [TaxId:9606]
    Gene: ERBB4, HER4
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q15303 (0-End)
      • conflict (523)
    Domains in SCOPe 2.08: d3u7ua1, d3u7ua2, d3u7ua3
  • Chain 'B':
    Compound: Receptor tyrosine-protein kinase erbB-4
    Species: Homo sapiens [TaxId:9606]
    Gene: ERBB4, HER4
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q15303 (0-End)
      • conflict (523)
  • Chain 'C':
    Compound: Receptor tyrosine-protein kinase erbB-4
    Species: Homo sapiens [TaxId:9606]
    Gene: ERBB4, HER4
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q15303 (0-End)
      • conflict (523)
  • Chain 'D':
    Compound: Receptor tyrosine-protein kinase erbB-4
    Species: Homo sapiens [TaxId:9606]
    Gene: ERBB4, HER4
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q15303 (0-End)
      • conflict (523)
  • Chain 'E':
    Compound: Receptor tyrosine-protein kinase erbB-4
    Species: Homo sapiens [TaxId:9606]
    Gene: ERBB4, HER4
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q15303 (0-End)
      • conflict (523)
  • Chain 'F':
    Compound: Receptor tyrosine-protein kinase erbB-4
    Species: Homo sapiens [TaxId:9606]
    Gene: ERBB4, HER4
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q15303 (0-End)
      • conflict (523)
  • Chain 'G':
    Compound: Neuregulin 1
    Species: Homo sapiens [TaxId:9606]
    Gene: NRG1
    Database cross-references and differences (RAF-indexed):
  • Chain 'H':
    Compound: Neuregulin 1
    Species: Homo sapiens [TaxId:9606]
    Gene: NRG1
    Database cross-references and differences (RAF-indexed):
  • Chain 'I':
    Compound: Neuregulin 1
    Species: Homo sapiens [TaxId:9606]
    Gene: NRG1
    Database cross-references and differences (RAF-indexed):
  • Chain 'J':
    Compound: Neuregulin 1
    Species: Homo sapiens [TaxId:9606]
    Gene: NRG1
    Database cross-references and differences (RAF-indexed):
  • Chain 'K':
    Compound: Neuregulin 1
    Species: Homo sapiens [TaxId:9606]
    Gene: NRG1
    Database cross-references and differences (RAF-indexed):
  • Chain 'L':
    Compound: Neuregulin 1
    Species: Homo sapiens [TaxId:9606]
    Gene: NRG1
    Database cross-references and differences (RAF-indexed):
  • Heterogens: NAG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3u7uA (A:)
qsvcagtenklsslsdleqqyralrkyyencevvmgnleitsiehnrdlsflrsvrevtg
yvlvalnqfrylplenlriirgtklyedryalaiflnyrkdgnfglqelglknlteilng
gvyvdqnkflcyadtihwqdivrnpwpsnltlvstngssgcgrchksctgrcwgptenhc
qtltrtvcaeqcdgrcygpyvsdcchrecaggcsgpkdtdcfacmnfndsgacvtqcpqt
fvynpttfqlehnfnakytygafcvkkcphnfvvdssscvracpsskmeveengikmckp
ctdicpkacdgigtgslmsaqtvdssnidkfinctkingnliflvtgihgdpynaieaid
peklnvfrtvreitgflniqswppnmtdfsvfsnlvtiggrvlysglsllilkqqgitsl
qfqslkeisagniyitdnsnlcyyhtinwttlfstinqrivirdnrkaenctaegmvcnh
lcssdgcwgpgpdqclscrrfsrgriciescnlydgefrefendsicvecdpqcekmedg
lltchgpgpdnctkcshfkdgpncvekcpdglqgansfifkyadpdrechpchpnctqgc
ngptshdciyypwtg

    Sequence, based on observed residues (ATOM records): (download) 
    >3u7uA (A:)
qsvcagtenklsslsdleqqyralrkyyencevvmgnleitsiehnrdlsflrsvrevtg
yvlvalnqfrylplenlriirgtklyedryalaiflnyrkdgnfglqelglknlteilng
gvyvdqnkflcyadtihwqdivrnpsnltlvssgcgrchksctgrcwgptenhcqtltrt
vcaeqcdgrcygpyvsdcchrecaggcsgpkdtdcfacmnfndsgacvtqcpqtfvynpt
tfqlehnfnakytygafcvkkcphnfvvdssscvracpsskmeveengikmckpctdicp
kacdgigtgslmsaqtvdssnidkfinctkingnliflvtgihgdpynaieaidpeklnv
frtvreitgflniqswppnmtdfsvfsnlvtiggrvlysglsllilkqqgitslqfqslk
eisagniyitdnsnlcyyhtinwttlfstinqrivirdnrkaenctaegmvcnhlcssdg
cwgpgpdqclscrrfsrgriciescnlydgefrefendsicvecdpqcekmedglltchg
pgpdnctkcs

  • Chain 'B':
    No sequence available.

  • Chain 'C':
    No sequence available.

  • Chain 'D':
    No sequence available.

  • Chain 'E':
    No sequence available.

  • Chain 'F':
    No sequence available.

  • Chain 'G':
    No sequence available.

  • Chain 'H':
    No sequence available.

  • Chain 'I':
    No sequence available.

  • Chain 'J':
    No sequence available.

  • Chain 'K':
    No sequence available.

  • Chain 'L':
    No sequence available.