PDB entry 3tz4

View 3tz4 on RCSB PDB site
Description: Crystal structure of branched-chain alpha-ketoacid dehydrogenase kinase/S-alpha-chloroisocaproate complex with ADP
Class: transferase/transferase inhibitor
Keywords: GHKL protein kinase, Allosteric kinase inhibitor,Branched-chain alpha-ketoacid, Branched-chain amino acids, Maple syrup urine disease,Diabetes and obesity, Bergerat nucleotide-binding fold, Protein kinase, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on 2011-09-27, released 2012-10-03
The last revision prior to the SCOPe 2.05 freeze date was dated 2013-05-29, with a file datestamp of 2013-05-24.
Experiment type: XRAY
Resolution: 2.25 Å
R-factor: 0.202
AEROSPACI score: 0.37 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial
    Species: Rattus norvegicus [TaxId:10116]
    Gene: Bckdk
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d3tz4a1, d3tz4a2
  • Heterogens: ADP, 03H, MG, K, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3tz4A (A:)
miltsvlgsgprsgsslwpllgsslslrvrstsatdthhvelarersktvtsfynqsaid
vvaekpsvrltptmmlysgrsqdgshllksgrylqqelpvriahrikgfrslpfiigcnp
tilhvhelyirafqkltdfppikdqadeaqycqlvrqllddhkdvvtllaeglresrkhi
edeklvryfldktltsrlgirmlathhlalhedkpdfvgiictrlspkkiiekwvdfarr
lcehkygnaprvringhvaarfpfipmpldyilpellknamratmeshldtpynvpdvvi
tianndvdliirisdrgggiahkdldrvmdyhfttaeastqdprisplfghldmhsggqs
gpmhgfgfglptsrayaeylggslqlqslqgigtdvylrlrhidgreesfrihhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >3tz4A (A:)
vrltptmmlysgrsqdgshllksgrylqqelpvriahrikgfrslpfiigcnptilhvhe
lyirafqkltdfppikdqadeaqycqlvrqllddhkdvvtllaeglresrkhiedeklvr
yfldktltsrlgirmlathhlalhedkpdfvgiictrlspkkiiekwvdfarrlcehkyg
naprvringhvaarfpfipmpldyilpellknamratmeshldtpynvpdvvitianndv
dliirisdrgggiahkdldrvmdyhfttagfgfglptsrayaeylggslqlqslqgigtd
vylrlrhidg