PDB entry 3tz2

View 3tz2 on RCSB PDB site
Description: Crystal structure of branched-chain alpha-ketoacid dehydrogenase kinase/phenylbutyrate complex
Class: transferase/transferase inhibitor
Keywords: GHKL protein kinase, Allosteric kinase inhibitor, Branched-chain alpha-ketoacid, Branched-chain amino acids, Maple syrup urine disease, Diabetes and obesity, Bergerat nucleotide-binding fold, Protein kinase, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on 2011-09-26, released 2012-10-03
The last revision prior to the SCOPe 2.04 freeze date was dated 2013-05-29, with a file datestamp of 2013-05-24.
Experiment type: XRAY
Resolution: 2.85 Å
R-factor: 0.204
AEROSPACI score: 0.27 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial
    Species: Rattus norvegicus [TaxId:10116]
    Gene: Bckdk
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d3tz2a1
  • Heterogens: CLT

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3tz2A (A:)
miltsvlgsgprsgsslwpllgsslslrvrstsatdthhvelarersktvtsfynqsaid
vvaekpsvrltptmmlysgrsqdgshllksgrylqqelpvriahrikgfrslpfiigcnp
tilhvhelyirafqkltdfppikdqadeaqycqlvrqllddhkdvvtllaeglresrkhi
edeklvryfldktltsrlgirmlathhlalhedkpdfvgiictrlspkkiiekwvdfarr
lcehkygnaprvringhvaarfpfipmpldyilpellknamratmeshldtpynvpdvvi
tianndvdliirisdrgggiahkdldrvmdyhfttaeastqdprisplfghldmhsggqs
gpmhgfgfglptsrayaeylggslqlqslqgigtdvylrlrhidgreesfrihhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >3tz2A (A:)
rltptmmlysgrsqdgshllksgrylqqelpvriahrikgfrslpfiigcnptilhvhel
yirafqkltdfppikdqadeaqycqlvrqllddhkdvvtllaeglresrkhiedeklvry
fldktltsrlgirmlathhlalhedkpdfvgiictrlspkkiiekwvdfarrlcehkygn
aprvringhvaarfpfipmpldyilpellknamratmeshldtpynvpdvvitianndvd
liirisdrgggiahkdldrvmdygfglptsrayaeylggslqlqslqgigtdvylrlrhi
d