PDB entry 3tti

View 3tti on RCSB PDB site
Description: Crystal Structure of JNK3 complexed with CC-930, an orally active anti-fibrotic JNK inhibitor
Class: transferase/transferase inhibitor
Keywords: Mitogen-Activated Protein Kinase 10, jnk3, Protein Kinase Inhibitors, kinase, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on 2011-09-14, released 2012-02-01
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-11-08, with a file datestamp of 2017-11-03.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: N/A
AEROSPACI score: 0.25 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Mitogen-activated protein kinase 10
    Species: Homo sapiens [TaxId:9606]
    Gene: JNK3, JNK3A, MAPK10, PRKM10
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d3ttia_
  • Heterogens: KBI, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3ttiA (A:)
mslhflyycseptldvkiafcqgfdkqvdvsyiakhynmskskvdnqfysvevgdstftv
lkryqnlkpigsgaqgivcaaydavldrnvaikklsrpfqnqthakrayrelvlmkcvnh
kniisllnvftpqktleefqdvylvmelmdanlcqviqmeldhermsyllyqmlcgikhl
hsagiihrdlkpsnivvksdctlkildfglartagtsfmmtpyvvtryyrapevilgmgy
kenvdiwsvgcimgemvrhkilfpgrdyidqwnkvieqlgtpcpefmkklqptvrnyven
rpkyagltfpklfpdslfpadsehnklkasqardllskmlvidpakrisvddalqhpyin
vwydpaeveapppqiydkqlderehtieewkeliykevmnseektkngvvkgqpspsgaa
vnsseslppsssvndissmstdqtlasdtdssleasagplgccr

    Sequence, based on observed residues (ATOM records): (download) 
    >3ttiA (A:)
nqfysvevgdstftvlkryqnlkpigsgaqgivcaaydavldrnvaikklsrpfqnqtha
krayrelvlmkcvnhkniisllnvftpqktleefqdvylvmelmdanlcqviqmeldher
msyllyqmlcgikhlhsagiihrdlkpsnivvksdctlkildfglasfmmtpyvvtryyr
apevilgmgykenvdiwsvgcimgemvrhkilfpgrdyidqwnkvieqlgtpcpefmkkl
qptvrnyvenrpkyagltfpklfpdslfpadsehnklkasqardllskmlvidpakrisv
ddalqhpyinvwydpaeveappprehtieewkeliykevmn