PDB entry 3tjo

View 3tjo on RCSB PDB site
Description: HtrA1 catalytic domain, mutationally inactivated
Class: hydrolase
Keywords: peptidase, hydrolase
Deposited on 2011-08-24, released 2012-05-16
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-07-29, with a file datestamp of 2020-07-04.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: N/A
AEROSPACI score: 0.33 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Serine protease HTRA1
    Species: Homo sapiens [TaxId:9606]
    Gene: HTRA, HTRA1, PRSS11
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q92743 (21-230)
      • expression tag (20)
      • engineered mutation (188)
    Domains in SCOPe 2.08: d3tjoa1, d3tjoa2
  • Chain 'B':
    Compound: Serine protease HTRA1
    Species: Homo sapiens [TaxId:9606]
    Gene: HTRA, HTRA1, PRSS11
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q92743 (21-230)
      • expression tag (20)
      • engineered mutation (188)
    Domains in SCOPe 2.08: d3tjob1, d3tjob2
  • Chain 'D':
    Compound: Serine protease HTRA1
    Species: Homo sapiens [TaxId:9606]
    Gene: HTRA, HTRA1, PRSS11
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q92743 (21-230)
      • expression tag (20)
      • engineered mutation (188)
    Domains in SCOPe 2.08: d3tjod1, d3tjod2
  • Heterogens: BOG, SO4, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3tjoA (A:)
mgsshhhhhhssglvprgshmdpnslrhkynfiadvvekiapavvhielfrklpfskrev
pvasgsgfivsedglivtnahvvtnkhrvkvelkngatyeakikdvdekadialikidhq
gklpvlllgrsselrpgefvvaigspfslqntvttgivsttqrggkelglrnsdmdyiqt
daiinygnaggplvnldgevigintlkvtagisfaipsdkikkflteshdr

    Sequence, based on observed residues (ATOM records): (download) 
    >3tjoA (A:)
mdpnslrhkynfiadvvekiapavvhielfrklpfskrevpvasgsgfivsedglivtna
hvvtnkhrvkvelkngatyeakikdvdekadialikidhqgklpvlllgrsselrpgefv
vaigspfslqntvttgivsttqdyiqtdaiinygnaggplvnldgevigintlkvtagis
faipsdkikkflteshdr

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3tjoB (B:)
mgsshhhhhhssglvprgshmdpnslrhkynfiadvvekiapavvhielfrklpfskrev
pvasgsgfivsedglivtnahvvtnkhrvkvelkngatyeakikdvdekadialikidhq
gklpvlllgrsselrpgefvvaigspfslqntvttgivsttqrggkelglrnsdmdyiqt
daiinygnaggplvnldgevigintlkvtagisfaipsdkikkflteshdr

    Sequence, based on observed residues (ATOM records): (download) 
    >3tjoB (B:)
mdpnslrhkynfiadvvekiapavvhielfrklpfskrevpvasgsgfivsedglivtna
hvvtnkhrvkvelkngatyeakikdvdekadialikidhqgklpvlllgrsselrpgefv
vaigspfslqntvttgivsttqdyiqtdaiinygnaggplvnldgevigintlkvtagis
faipsdkikkflteshdr

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >3tjoD (D:)
mgsshhhhhhssglvprgshmdpnslrhkynfiadvvekiapavvhielfrklpfskrev
pvasgsgfivsedglivtnahvvtnkhrvkvelkngatyeakikdvdekadialikidhq
gklpvlllgrsselrpgefvvaigspfslqntvttgivsttqrggkelglrnsdmdyiqt
daiinygnaggplvnldgevigintlkvtagisfaipsdkikkflteshdr

    Sequence, based on observed residues (ATOM records): (download) 
    >3tjoD (D:)
mdpnslrhkynfiadvvekiapavvhielfrklpfskrevpvasgsgfivsedglivtna
hvvtnkhrvkvelkngatyeakikdvdekadialikidhqgklpvlllgrsselrpgefv
vaigspfslqntvttgivsttdyiqtdaiinygnaggplvnldgevigintlkvtagisf
aipsdkikkflteshdr